| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
We developed the following synthetic methods in this study. (1) We developed a silver-caebenoid mediate ipso-Friedel-Crafts type intramolecular dearomatization of phenols. This process could be extended to the asymmetric reaction using chiral phosphoric acid ligands. (2) We developed a synthetic method of 3,4-fused tricyclic indole derivatives using 3,4-fused 3-alkylidene indolines as their precursors. Two types of cascade processes were developed based on palladium catalysis and platinum catalysis. (3) Using the developed methods, we succeeded in the total synthesis of (-)-aurantioclavine and fargesine. Synthetic studies of dragmacidin E were also examined using the developed palladium catalysis. In addition, we developed a synthetic method of 3,4-fused tetrahydrobenzopyranes using para-quinonemethides as key intermediates.
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