Synthetic study of ellagitannins based on coupling reactions between two aromatic rings
| Project/Area Number |
15K07854
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
Abe Hitoshi 富山大学, 大学院理工学研究部(工学), 教授 (70221728)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 全合成 / 芳香族化合物 / カップリング反応 / グルコース / ポリフェノール / Ullmann 反応 / 軸不斉 / 没食子酸 / 酸化的フェノールカップリング / エラジタンニン / Ullmann反応 |
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| Outline of Final Research Achievements |
Although ellagitannins, which are natural polyphenol compounds, composed of only limited structures, glucose and gallic acid, many kinds of compounds have been known. Since ellagitannin compounds often exhibit interesting biological activities, they have been expected to be medicinal seeds. However, studies on organic synthesis of ellagitannins have insufficiently progressed, and a few examples of total synthesis of simple ellagitannins have been reported. In this study, we challenged syntheses of complex-structured ellagitannins based on coupling reactions between two gallic acids, involving the C-C or C-O oxidative coupling.
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Report
(4 results)
Research Products
(23 results)
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[Presentation] ニグリカニンの合成2016
Author(s)
永井孝典、今井遥、堀野良和、阿部仁
Organizer
有機合成化学北陸セミナー
Place of Presentation
金沢
Year and Date
2016-10-07
Related Report
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