New development of cycloaddition reactions using cyclobutanones
| Project/Area Number |
15K07855
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIMURA Tomoyuki 金沢大学, 医薬保健研究域薬学系, 准教授 (20432320)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | シクロブタノン / 付加環化 / 環化付加反応 / 結合開裂 / 有機合成 / 反応開発 / 炭素ー炭素結合 / 環化付加 |
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| Outline of Final Research Achievements |
1,4-Zwitterionic intermediates which were generated by activation of 3-ethoxycyclobutanones with an appropriate Lewis acid reacted with azobenzenes, quinolines, isoquinolines, ynamides, nitrosobenzenes, and reactive alkynes gave the corresponding 6-membered cyclic compounds by formal [4+2] cycloaddition reactions. A zwitterionic intermediate generated from 3-phenylcyclobutanones reacted aromatics to afford Friedel-Crafts adducts. Also, an adduct between 1,4-ketoaldehyde and tosylhydrazine rected with nucleophiles under activation with a Lewis acid to give dihydropyridazines.
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Report
(4 results)
Research Products
(26 results)
