| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In recent years, selenium-containing biomolecules have been documented as promising pharmacological agents. We initially explored an efficient method for the synthesis of 5’-selenium modified nucleosides based on the idea of direct functionalization of 2-(trimethylsilyl)ethyl (TSE) selenyl groups. This method was successfully applied to the synthesis of highly functionalized nucleoside, Se-adenosyl-L-selenomethionine (SeAM). In addition, we developed a valuable route for the synthesis of 2’-alkylselenouridine derivatives via a 2-(trimethylsilyl)ethylselenation approach. Furthermore, we applied the 2-TSE selenyl group to the synthesis of selenium-containing amino acid derivatives including biologically important selenocysteine (Sec) and selenoglutathione (GSeH) derivatives. Our findings highlight the great utility and versatility of the 2-TSE selenyl group as a selenating reagent into biomolecules.
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