Development and applications of novel methodologies for the construction of asymmetric tetrasubstituted carbon stereocenters
| Project/Area Number |
15K07860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 有機合成化学 / 不斉四置換炭素 / 触媒 / 環境調和型反応 / グリーンケミストリー / アミノ酸 |
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| Outline of Final Research Achievements |
In this research, we achieved the design of novel highly active catalysts based on detailed mechanistic studies and their application to the synthesis of asymmetric tetrasubstituted carbon stereocenters, resulted in the construction of a new chemical library of amino acid derivatives with tetrasubstituted carbon stereocenters.
In addition, we succeeded in developing environmentally friendly new catalytic asymmetric tetrasubstituted carbon synthesis using unprotected imines and paved the new way for the synthesis of unprotected amines.
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Report
(4 results)
Research Products
(53 results)
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[Presentation] Direct Catalytic Asymmetric Alkynylation of Ketimines2016
Author(s)
◯Sawa Masanao1、Morisaki Kazuhiro1、Yonesaki Ryohei1、Morimoto Hiroyuki1、Mashima Kazushi2、Ohshima Takashi1
Organizer
Molecular Chirality Asia 2016
Place of Presentation
Knowledge Capital Congres Convention Center, Osaka, Japan
Year and Date
2016-04-20
Related Report
Int'l Joint Research
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[Presentation] Direct Catalytic Enantioselective Alkynylation of Ketimines2015
Author(s)
◯Kazuhiro Morisaki, Masanao Sawa, Ryohei Yonesaki, Jun-ya Nomaguchi, Yousuke Takeuchi, Hiroyuki Morimoto, Kazushi Mashima, Takashi Ohshima （九州大学大学院薬学研究院、大阪大学基礎工学研究科）
Organizer
The 5th Junior International Conference on Cutting-edge Organic Chemistry in Asia (5th Junior ICCEOCA)
Place of Presentation
National Taiwan Normal University, Taiwan
Year and Date
2015-10-30
Related Report
Int'l Joint Research
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[Presentation] Direct Catalytic Asymmetric Alkynylation of Ketimines2015
Author(s)
◯Sawa Masanao1, Morisaki Kazuhiro1, Yonesaki Ryohei1, Morimoto Hiroyuki1, Mashima Kazushi2, Ohshima Takashi1 （1.九州大学大学院薬学研究院 2.大阪大学大学院基礎工学研究科 ）
Organizer
7th International Conference on Green and Sustainable Chemistry - 4th JACI-GSC Symposium（第4回 JACI/GSCシンポジウム）
Place of Presentation
一橋大学（東京）
Year and Date
2015-07-05
Related Report
Int'l Joint Research
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