| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In late years, apoptosis has been revealed to play an important role for cancer and autoimmune disease. Portimine is a polycyclic marine toxin isolated from the dinoflagellate. The biological studies of this compound indicated that it has potent antitumor activity and also shows the activation of caspases indicating apoptotic activity. In this work, we studied the synthesis of portimine, which contains five-membered cyclic mine moiety and remarkable dioxabicyclo[6.2.1]undecanone embedded in macrocyclic framework. Brown's asymmetric crotylation and silyl linkage-mediated coupling afforded an acyclic key intermediate. This acyclic compound was subjected to acid to generate a core acetal.
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