| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The efficient transition metal-catalyzed deuteration methods have been successfully developed with novel unsymmetrical N-heterocyclic carbene (NHC) ligands. In the palladium-catalyzed deuterodechlorination of aryl chlorides, a bulky NHC ligand proved to be effective, and a number of substrates with various functional groups and heterocyclic moieties were tolerated. The catalytic deuteration with a pharmaceutical molecule as a substrate was also achieved in gram-scale. The catalytic deoxygenative deuteration method was also developed, and a variety of aryl sulfamates derived from phenols were efficiently converted to deuterated molecules with a nickel/unsymmetrical NHC system, in which nickel catalysts and phenol derivatives are advantageous because of their lower level of costs and high natural abundance.
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