| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Outline of Final Research Achievements |
A heterogeneous palladium catalyst supported on an anion exchange resin bearing N,N-dimethylamino functionalities on the polystyrene-type polymer backbone (7% Pd/WA30) was developed in expectation of the ligand effect of the amino functionalities to the palladium metal. The 7% Pd/WA30 was found to effectively catalyze the Suzuki-Miyaura reaction using less reactive aromatic chlorides owing to the expected function of the amino functionalities as the ligands. The heteroaromatic chlorides, which would suppress the reaction due to the catalytic poisonous property based on the coordination of their heteroatoms to the palladium metals, could also be applied as the substrates. The present reaction is expected to be applied in process chemistry field that is directly connected with drug discovery process due to the prevention of metal contamination since no palladium species was detected in the reaction media.
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