| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Our efficient synthesis of tetrasubstituted allenes was applied to total synthetic studies on natural products. In the synthesis of raputindole A, the allene obtained underwent the intramolecular cyclization to give the tricyclic skeleton. Chelation-controlled reduction was carried out, followed by the introduction of side chains to access raputindole A. Moreover, tetrasubstituted allene was synthesized as a key intermediate toward the total synthesis of taiwaniaquinol D.
In order to develop a synthesis of optically active tetrasubstituted allenes using dynamic kinetic resolution, a racemization catalyst of propargyl alcohols and a chiral silver catalyst that catalyzes sigmatropic rearrangement were investigated.
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