| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Trypanosomiasis is caused by the parasitic flagellated protozoa. During the course of physicochemical screening for metabolites, new anti-trypanosomal macrolides, actinoallolides, were discovered. Among them, actinoallolide A showed most potent and selective anti-trypanosomal activity. Due to its intriguing architectural structure and interesting biological activity, we thus became interested to determination of their absolute and total synthesis of actinoallorides.
We first determined the absolute configuration of actinoalloride A by single-crystal X-ray crystallographic analysis of its acylation derivative. We next commenced to pursue the synthetic studies of actinoalloride A to provide clarification of detailed structure-activity relationships. So far, we have achieved the synthesis of an essential intermediate including full carbon framework in the total synthesis of Actinoallolide A.
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