| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
1) In the course of screening program of microbial origins, we discovered new macrolactam and anthraquinone compounds that exhibit antimycobacterial activity against M. bovis BCG, M. avium and M. intraceullare. 2) We studied the mechanism of action of microbial small compounds with unique chemical structure and biological activity. We found that stemphone is bound to FemA, leading to the inhibition of the enzymatic activity of FemA. Furthermore, we searched for binding proteins of tanzawaic acid in the lysate of R. oryzae and identified homoisocitrate dehydrogenase as a potential target protein.
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