Discovery of new anti-infectives based on chemical biology
| Project/Area Number |
15K07867
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Research Collaborator |
NAGAI KENICHIROU 北里大学, 薬学部, 助教 (30321649)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ケミカルバイオロジー / 抗感染症剤 / MRSA / 結核症 / MAC症 / 真菌症 / 肺MAC症 / 肺 MAC 症 |
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| Outline of Final Research Achievements |
1) In the course of screening program of microbial origins, we discovered new macrolactam and anthraquinone compounds that exhibit antimycobacterial activity against M. bovis BCG, M. avium and M. intraceullare. 2) We studied the mechanism of action of microbial small compounds with unique chemical structure and biological activity. We found that stemphone is bound to FemA, leading to the inhibition of the enzymatic activity of FemA. Furthermore, we searched for binding proteins of tanzawaic acid in the lysate of R. oryzae and identified homoisocitrate dehydrogenase as a potential target protein.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides2016
Author(s)
Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL Jr, Ghequire MG, Carrion VJ, Cheng TL, Duggan BM, Malone JG, Mauchline TH, Sanchez LM, Kilpatrick AM, Raaijmakers JM, Mot R, Moore BS, Medema MH, Dorrestein PC
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Journal Title
Nat Microbiol
Volume: 2
Issue: 1
Pages: 16197-16197
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Identification and characterization of natural microbial products that alter the free d-aspartate content of mammalian cells2016
Author(s)
Katane M, Kaneko Y, Watanabe M, Doi Y, Tanaka T, Kasuga Y, Yoshida N, Kumakubo S, Nakayama K, Matsuda S, Furuchi T, Saitoh Y, Sekine M, Koyama N, Tomoda H, Homma H
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Journal Title
Bioorg Med Chem Lett
Volume: 26
Issue: 2
Pages: 556-560
DOI
Related Report
Peer Reviewed
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