| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Novel fluorescent quinazolines were designed and synthesized, including derivatives with high quantam yield, red-emission, and large Stokes shift. The HOMO-LUMO energy gaps calculated from the results of UV spectra and CV experiments were consistent with DFT calculation.
Synthesized quinaolines with a metal-recognition moiety responded to a certain type of metal ions. An anti-cancer fluorescent quinazoline was used as a fluorescent probe in cultured cancer cells to visualize its intracellular distribution by fluorescence microscopy. It can be used as a tool for further study to elucidation of its action mechanism.
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