Development of fluorescent quinazolines as ion probes
| Project/Area Number |
15K07868
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Sophia University |
|---|
Principal Investigator |
Suzuki Yumiko 上智大学, 理工学部, 准教授 (20295546)
|
|---|
| Research Collaborator |
MOTOYAMA Miho 上智大学, 大学院・理工学研究科
OTAKE Ryo 上智大学, 大学院・理工学研究科
FUJIMAKI Yuki 上智大学, 大学院・理工学研究科
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 蛍光団 / 分子プローブ / キナゾリン / 蛍光プローブ / フォトルミネッセンス / 金属イオンセンサー |
|---|
| Outline of Final Research Achievements |
Novel fluorescent quinazolines were designed and synthesized, including derivatives with high quantam yield, red-emission, and large Stokes shift. The HOMO-LUMO energy gaps calculated from the results of UV spectra and CV experiments were consistent with DFT calculation.
Synthesized quinaolines with a metal-recognition moiety responded to a certain type of metal ions. An anti-cancer fluorescent quinazoline was used as a fluorescent probe in cultured cancer cells to visualize its intracellular distribution by fluorescence microscopy. It can be used as a tool for further study to elucidation of its action mechanism.
|
Report
(4 results)
Research Products
(51 results)
