| Project/Area Number |
15K07871
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Toho University |
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Principal Investigator |
KATO Keisuke 東邦大学, 薬学部, 教授 (80276609)
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| Co-Investigator(Kenkyū-buntansha) |
日下部 太一 東邦大学, 薬学部, 講師 (00600032)
高橋 圭介 東邦大学, 薬学部, 准教授 (60380854)
高山 博之 日本薬科大学, 薬学部, 准教授 (60406634)
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| Co-Investigator(Renkei-kenkyūsha) |
MOCHIDA Tomoyuki 神戸大学, 理学研究科, 教授 (30280580)
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| Research Collaborator |
HOU Tei
ARIYAMA Tomohiro
LI Tou
CHIN Yu
YOGESH Daulat Dhage
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | カルボニル化 / リガンド / 環化‐不斉二量化 / パラジウム / ビスオキサゾリン / ビベンゾチオフェン / CCC-カップリング / 環化 / 不斉二量化 |
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| Outline of Final Research Achievements |
Previously, we found that bis(oxazoline) (box) ligand enhances the alkynophilicity of palladium (II), and we were successful in developing CCC-coupling reaction. Herein we report some useful findings based on the characteristic properties of ligand, 1) Box-palladium complexes catalyzed hydration of alkynes 2) Box-palladium complexes catalyzed cyclization- cyclization asymmetric coupling reaction of (ortho-alkynyl phenyl) (methoxymethyl) sulfides 3) Box-palladium complexes catalysed CCC-coupling reaction using molecular oxygen as the terminal oxidant 4) Palladium catalyzed ligand controlled synthesis of heterocycle-carboxylates and diheteroarylketones.
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