| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The expansion of the substrates for the diastereoselective ketal formation reaction have been established as my primary object. The products of the diastereoselective ketal formation seem to be useful for synthetic organic chemistry. Therefore, I have arranged the synthesis of the important compounds as an optically active form for my second object.
Firstly, compounds having an aromatic ring and cinnamyl unit at C2 position of 1,3-cyclohexanedione have been synthesized and highly diastereoselective hemiketal and intermolecular ketal formation reaction have been achieved. Next, the asymmetric dihydroxylation reaction was examined utilizing commercially available reagents. As a result, the products which have almost 90%e.e. were afforded. Secondly, the conversion of the quaternary carbon center to chiral four substituted center was investigated and single lactam was obtained by Beckmann rearrangement. Synthetic studies of two natural products as optically active forms are now under way.
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