An Approach to Develop High-Performance Photosensitizers Based on Silyl-Substituted Porphyrin Molecules for Photodynamic Therapy
| Project/Area Number |
15K07874
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 光線力学治療 / ポルフィリン光増感剤 / ケイ素官能基 / 酸化電位 / 吸収波長 / βーシリル化 / meso-シリル化 / シリル亜鉛反応剤 / C-H活性化 / βｰシリル化 / イリジウム触媒 |
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| Outline of Final Research Achievements |
Photodynamic therapy (PDT) has been extensively considered as a promising and minimally invasive strategy for cancer therapy. The main two concerns associated with certain clinically-used PDT sensitizers are low tissue-penetrating depth of light and potential phototoxicity, which are expected to be solved by developing new PDT sensitizers that have a higher absorption coefficient in longer wavelength region, show lower cytotoxicity, and can quickly be excreted from human body by drug detoxification in a shorter time. Described herein is the synthesis, characterization, and photo- and electrochemical properties of meso- and β-sily-substituted porphyrins. Their unique optical- and electrochemical properties imply that the silyl-substituted porphyrin derivatives could be a promising anticancer agent for photodynamic therapy.
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Report
(4 results)
Research Products
(40 results)
