| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Photodynamic therapy (PDT) has been extensively considered as a promising and minimally invasive strategy for cancer therapy. The main two concerns associated with certain clinically-used PDT sensitizers are low tissue-penetrating depth of light and potential phototoxicity, which are expected to be solved by developing new PDT sensitizers that have a higher absorption coefficient in longer wavelength region, show lower cytotoxicity, and can quickly be excreted from human body by drug detoxification in a shorter time. Described herein is the synthesis, characterization, and photo- and electrochemical properties of meso- and β-sily-substituted porphyrins. Their unique optical- and electrochemical properties imply that the silyl-substituted porphyrin derivatives could be a promising anticancer agent for photodynamic therapy.
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