| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In order to efficiently construct optically active N-heterocyclic frameworks, which can be found in a large number of bioactive compounds, (3+2) annulations catalyzed by chiral phosphines were investigated. Planar chiral [2.2]paracyclophane-based phosphine-phenols, originally developed by us, catalyzed (3+2) annulations of allenoate with N-tosylaldimines to produce 2,5-dihydropyrroles in high regio- and enantioselectivity. Our catalysts also realized the (3+2) cyclization of allenoate or MBH carbonates with methyleneindolinones to give spirooxindoles in highly regio-, diastereo- and enantioselective manner.
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