| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Imidazolinone analogs, geo-DAIN, having an asymmetric diarylmethylene moiety were designed and synthesized. Geo-DAIN is a green fluorescent protein chromophore analog and afforded E, Z-geometrical isomers. The geo-DAIN synthesis was performed by a condensation reaction with imidate and imino-ester. Both isomers of geo-DAIN were reversibly transformed each other by irradiation with different wavelength light. In addition, both isomers afforded different color emission between E and Z form at a powder state and a frozen solution. Such properties could apply for a fluorescence turn-on system that affords dual emission.
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