Highly efficient domino reaction of alkoxyimines bearing multiple bond
| Project/Area Number |
15K07877
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
Ueda Masafumi 神戸薬科大学, 薬学部, 准教授 (00340935)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | イソキサゾール / イソキサゾリジン / インドール / 金触媒 / 閉環反応 / 転位反応 / Fischer型インドール合成 / ハロ環化 / 付加環化反応 / 架橋型複素環 / ドミノ反応 / アルキン / アルコシキイミン / 共役ヒドラゾン / ヨウ化t-ブチル / インドール合成 |
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| Outline of Final Research Achievements |
In order to develop novel synthetic methods for preparation of heterocyclic compounds, we investigated several domino reactions. Gold-catalyzed domino reaction of N-alkoxyimines and N-alkoxyamides bearing alkyne moiety via cyclization and rearrangement or cycloaddition provided 3-hydroxyisoxazoles and bridged isoxazolidines. Reductive Fischer indolization of conjugated hydrazones to give various indole derivatives been also developed.
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Report
(4 results)
Research Products
(18 results)
