Evaluation of molecular state of drug nanosuspensions by suspended-state NMR spectroscopy
| Project/Area Number |
15K07885
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
森部 久仁一 千葉大学, 大学院薬学研究院, 教授 (50266350)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬物ナノ懸濁液 / NMR / 固液界面 / 運動性 / 分子間相互作用 / 結晶多形 / 非晶質 / 湿式粉砕 / Suspended state NMR / 薬物ナノ粒子 / 多形 / 難水溶性薬物 / indomethacin / piroxicam / poloxamer / ナノ懸濁液 / suspended state NMR / 表面構造 / 分散安定性 / Indometacin / Poloxamer / ナノ粒子 / Cryo-TEM |
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| Outline of Final Research Achievements |
Two species of drug nanosuspensions prepared by wet-milling were evaluated by suspended-state NMR spectroscopy. We succeeded in directly clarifying the molecular state of both drug and stabilizer of drug nanoparticle in suspended-state. The knowledge obtained in this study provides a new insight into the mechanism of formation and stabilization of drug nanosuspensions. This study also shows that suspended-state NMR spectroscopy is a useful analytical method for quality assessment of drug nanosuspension formulations. We expect that this study will become a new index in development for drug nanosuspension and will be a help to design a new drug nanosuspension formulations of high quality.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] A solid-phase mediated methodology to incorporate drug into intermolecular spaces of CD columns in the PEG/CD-polypseudorotaxanes by cogrinding and subsequent heating2017
Author(s)
Ogawa, M., Higashi, K., Namiki, S., Liu, N. Ueda, K., Limwikrant, W., Yamamoto, K., Moribe, K.
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Journal Title
Cryst. Growth Des.
Volume: 17(3)
Issue: 3
Pages: 1055-1068
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Molecular-level understanding of the encapsulation and dissolution of poorly water-soluble ibuprofen by functionalized organic nanotubes using solid-state NMR spectroscopy.2016
Author(s)
Liu, N., Higashi, K., Kikuchi, J., Ando, S., Kameta, N., Ding, W., Masuda, M., Shimizu, T., Ueda, K., Yamamoto, K., Moribe, K.
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Journal Title
J. Phys. Chem B
Volume: 120(19)
Issue: 19
Pages: 4496-4507
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Characterization of glibenclamide amorphous nanoparticles prepared by antisolvent method: Effect of hypromellose addition method2017
Author(s)
Higashi, K., Yonashiro, H., Ueda K., Itoh, T., Itoh, Masataka, Masu, H., Noguchi, S., Moribe, K.
Organizer
Asian federation pharmaceutical sciences 2017
Related Report
Int'l Joint Research / Invited
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[Presentation] Characterization of the mechanism of drug dissolution enhancement by saccharin addition from phenytoin/Eudragit E PO solid dispersion2016
Author(s)
Higashi, K., Ueda, K., Kanaya, H., Yamamoto, K., Moribe, K.
Organizer
58th Annual International Industrial Pharmaceutical Research and Development Conference
Place of Presentation
Madison,USA
Year and Date
2016-06-06
Related Report
Invited
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