| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We tried to manufacture the two-layer sheet formulation containing anticancer drug 5-FU and metabolic inhibitors for application to liver surface. In addition, we examined the influence of viscous additives on the hepatic disposition of 5-FU, aiming to optimize the sheet formulation. We could manufacture the two-layer sheet formulation containing anticancer drug 5-FU for application to liver surface by employing biodegradable macromolecules and hydroxypropyl cellulose. The two-layer sheet could increase the availability of 5-FU in the specific region in the liver. Moreover, we found that the accumulation of 5-FU in the liver was improved in the tumor mice model.
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