Development of two-layer sheet formulation for application to liver surface to attain specific local chemotherapy
| Project/Area Number |
15K07891
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
NISHIDA Koyo 長崎大学, 医歯薬学総合研究科(薬学系), 教授 (20237704)
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| Research Collaborator |
SHIMOKAWA Kenta
HIRATA Haruna
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | コントロールドリリース / DDS製剤 / 薬物吸収 / 抗癌薬 / 徐放化製剤 / 肝臓内動態 / 代謝阻害剤 / がん / 放出制御 |
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| Outline of Final Research Achievements |
We tried to manufacture the two-layer sheet formulation containing anticancer drug 5-FU and metabolic inhibitors for application to liver surface. In addition, we examined the influence of viscous additives on the hepatic disposition of 5-FU, aiming to optimize the sheet formulation. We could manufacture the two-layer sheet formulation containing anticancer drug 5-FU for application to liver surface by employing biodegradable macromolecules and hydroxypropyl cellulose. The two-layer sheet could increase the availability of 5-FU in the specific region in the liver. Moreover, we found that the accumulation of 5-FU in the liver was improved in the tumor mice model.
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Report
(4 results)
Research Products
(9 results)
