Development of early detection method for Chronic Obstructive Pulmonary Disease
| Project/Area Number |
15K07892
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
SHIBATA Takayuki 長崎大学, 医歯薬学総合研究科(薬学系), 助教 (10448491)
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| Research Collaborator |
SHIMAMURA Ryosuke
SAKURAI Hiroki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 慢性閉塞性肺疾患 / ペプチド / 蛍光 / 臨床検査 / 蛍光反応 / 喀痰 / 血液 / ﾍﾟﾌﾟﾁﾄﾞ / 血液検査 |
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| Outline of Final Research Achievements |
The aim of the present research is the development of an early detection method for Chronic Obstructive Pulmonary Disease (COPD). For this purpose, the peptide sequence-specific fluorescence derivatization reaction has been utilized in order to detect the proline-glycine-proline tripeptide which is known as a biomarker for COPD. The sputum sample from a COPD patient was applied to the fluorescence reaction, and the resulting supernatant was analyzed with high-performance liquid chromatography. As the result, a minimal amount of the target marker was successfully quantified.
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Report
(4 results)
Research Products
(25 results)
