| Project/Area Number |
15K07904
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | Meijo University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 吸入粉末剤 / 多孔性微粒子 / 粒度分布 / 空気力学的質量中位径 / 耐吸湿性 / 崩壊性 / 当てはめ計算 / 噴霧急速凍結乾燥法 / 吸湿性 / 分散性 |
|---|
| Outline of Final Research Achievements |
Inhalation therapy is widely applied to treat pulmonary disorders such as asthma and COPD. However, low availability of an inhaled formulation at deep lungs is a problem to be solved. I designed several prototype porous formulations with high flowability, dispersibility, and antihygroscopicity, which are broken into tiny segments by inhalation, delivered deep into the lungs, and swell up for a short term to remain on the surface of lung epithelium at a high extent. It was suggested that spray-freeze-drying aqueous solutions composed of excipients contributing to antihygroscopicity, disintegrability, and hygroscopicity at proper compositions gave aimed powders. The present study is unique and shows a new strategy to develop dry powder inhalers with high performance.
|
| Academic Significance and Societal Importance of the Research Achievements |
耐吸湿性に優れ吸入時に崩壊・膨潤する吸入粉末剤の概念はこれまでになく、学術的に吸入粉末剤の新たな方向性を示すものである。吸入療法は患者の吸入手技による吸入効率のばらつきが大きい。吸入効率が高い吸入粉末剤は吸入療法の個人差を抑えることができ、社会的に貢献できる。吸入療法は今後遺伝子や抗体医薬など高額な医薬品に拡大され可能性が高い。最深部送達率が高い吸入粉末剤を実用化することで、医療経済的にも貢献できる。
|
