| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
We synthesized a nitroxyl radical-binding phospholipid and prepared a redox sensitive liposome. It is difficult to measure the in vivo redox by an in vivo ESR technique using a nitroxyl radical in a disease model having renal impairment, because the half-life of a nitroxyl radical is short. However, we achieved increase of retention in the body of the nitroxyl radical by producing a redox sensitive liposome. This would lead to increase of target diseases of non-invasive redox measurement by ESR and MRI, because difference of probe concentration in a body between healthy and disease model animals would decrease.
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