Regulation of cell proliferation through tyrosine phosphorylation signaling in the nucleus
Project/Area Number |
15K07922
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Chiba University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
山口 憲孝 千葉大学, 大学院薬学研究院, 准教授 (80399469)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 核内チロシンリン酸化 / Abl / Src / 転写因子 / 転写制御因子 / がん / シグナル伝達 / クロマチンリモデリング / チロシンリン酸化 / 核内シグナル / 転写調節因子 / ALK / SKIP / AKAP8 / DNA結合蛋白質 / Ku70 / FoxA1 / クロマチン / HDAC1 / JunB / c-Abl / Fyn |
Outline of Final Research Achievements |
Abnormal tyrosine phosphorylation signaling causes major diseases, such as carcinogenesis, autoimmune diseases, diabetes, arteriosclerosis. In this study, we identified novel substrates of Src or Abl tyrosine kinase and determined their tyrosine phosphorylation sites. Consequently, we revealed that tyrosine phosphorylation of some nuclear transcription regulatory factors is involved in control of chromatin remodeling. It would be the first step to find a drug target having an excellent effect and less adverse effects, because tyrosine phosphorylation signaling in the nucleus has no divergent pathways and is located far downstream of the signal transduction pathways.
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Report
(4 results)
Research Products
(110 results)
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[Journal Article] Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP).2017
Author(s)
Kuki K, Yamaguchi N, Iwasawa S, Takakura Y, Aoyama K, Yuki R, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N
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Journal Title
Biochemical and biophysical research communications
Volume: 490
Issue: 3
Pages: 1045-1051
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Src acts as an effector for Ku70-dependent suppression of apoptosis through phosphorylation of Ku70 at Tyr-5302017
Author(s)
Morii, M., Kubota, S., Honda, T., Yuki, R., Morinaga, T., Kuga, T., Tomonaga, T., Yamaguchi, N.-t., and Yamaguchi, N.
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Journal Title
Journal of Biological Chemistry
Volume: 292
Issue: 5
Pages: 1648-1665
DOI
Related Report
Peer Reviewed
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[Journal Article] Protective role for lipid modifications of Src-family kinases against chromosome missegregation2016
Author(s)
Honda, T., Soeda, S., Tsuda, K., Yamaguchi, C., Aoyama, K., Morinaga, T., Yuki, R., Nakayama, Y., Yamaguchi, N.-t., and Yamaguchi, N.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 38751-38751
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] c-Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity-dependent manner.2015
Author(s)
Kazumasa Aoyama, Noritaka Yamaguchi, Ryuzaboro Yuki, Mariko Morii, Sho Kubota, Kensuke Hirata, Kohei Abe, Takuya Honda, Takahisa Kuga, Yuuki Hashimoto, Takeshi Tomonaga, and Naoto Yamaguchi
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Journal Title
Cell Biology International
Volume: 39
Issue: 4
Pages: 446-456
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Overexpression of Zinc-finger protein 777 (ZNF777) inhibits proliferation at low cell density through down-regulation of FAM129A.2015
Author(s)
Yuki, R., Aoyama, K., Kubota, S., Yamaguchi, N.-t., Kubota, S.-i., Hasegawa, H., Morii, M., Huang, X., Liu, K., Williams, R., Fukuda, M.N., and Yamaguchi, N.
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Journal Title
J. Cell. Biochem.
Volume: in press
Issue: 6
Pages: 954-968
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] がん遺伝子v-Srcによる細胞周期進行抑制の分子機構.2017
Author(s)
本田拓也, 鈴木 亘, 森井真理子, 添田修平, 阿部紘平, 山口千尋, 久保田 翔, 青山和正, 中山祐治, 山口憲孝, 山口直人.
Organizer
第137回日本薬学会年会
Place of Presentation
東北大学・仙台国際センター, 仙台
Year and Date
2017-03-25
Related Report
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[Presentation] v-Srcによる多極紡錘体の形成.2016
Author(s)
抱 恵子, 池内正剛, 本田拓也, 久家貴寿, 齊藤洋平, 山口直人, 中山祐治.
Organizer
第39回日本分子生物学会年会
Place of Presentation
パシフィコ横浜, 横浜
Year and Date
2016-11-30
Related Report
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[Presentation] The effect of the oncogenic v-Src on cell cycle progression.2016
Author(s)
Takuya Honda, Ko Suzuki, Mariko Morii, Shuhei Soeda, Kohei Abe, Chihiro Yamaguchi, Sho Kubota, Kazumasa Aoyama, Yuji Nakayama, Noritaka Yamaguchi, and Naoto Yamaguchi.
Organizer
The 7th EMBO meeting 2016
Place of Presentation
The Rosengarten Conference Centre, Manheim, Germany
Year and Date
2016-09-10
Related Report
Int'l Joint Research
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[Presentation] 乳がん増殖因子FOXA1と上皮間葉転換の関連性.2016
Author(s)
安斎絵里菜, 山口憲孝, 山田千愛, 柴崎美里, 平田健介, 森井真理子, 山口直人.
Organizer
日本薬学会生物系薬学部会 第15回次世代を担う若手ファーマ・バイオフォーラム2016
Place of Presentation
大阪大学大学院薬学研究科, 大阪
Year and Date
2016-09-10
Related Report
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[Presentation] 核内c-Ablの新規チロシンリン酸化基質の解析.2016
Author(s)
帯刀 隆, 本田拓也, 森井真理子, 岩澤脩斗, 鈴木 亘, 山口憲孝, 山口直人.
Organizer
日本薬学会生物系薬学部会 第15回次世代を担う若手ファーマ・バイオフォーラム2016
Place of Presentation
大阪大学大学院薬学研究科, 大阪
Year and Date
2016-09-10
Related Report
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[Presentation] Trafficking of acetyl-C16-ceramide-NBD with long-term stability and no cytotoxicity into the Golgi complex.2016
Author(s)
Hiroyuki Nakamura, Tomohiko Makiyama, Nobuo Nagasaka, Hisahiro Yamashita, Takuya Honda, Naoto Yamaguchi, Atsushi Nishida, and Toshihiko Murayama
Organizer
The 2016 Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB)
Place of Presentation
The San Diego Convention Center, San Diego, CA, USA
Year and Date
2016-04-02
Related Report
Int'l Joint Research
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[Presentation] Search for a tyrosine-phosphorylated protein involved in Src-mediated antiapoptosis.2016
Author(s)
Mariko Morii, Sho Kubota, Takuya Honda, Kazumasa Aoyama, Ryuzaburo Yuki, Shiori Kometani, Noritaka Yamaguchi, and Naoto Yamaguchi.
Organizer
The 2016 Gordon Research Seminar on DNA Damage, Mutation and Cancer
Place of Presentation
Ventura Beach Marriott, Ventura, California, U.S.A.
Year and Date
2016-03-13
Related Report
Int'l Joint Research
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[Presentation] 分裂期紡錘体におけるチロシンリン酸化の機能解析.2015
Author(s)
榎本杏子, 米谷詩織, 森井真理子, 平田健介, 佐藤里香, 阿蘇拓也, 山口憲孝, 山口直人.
Organizer
BMB2015(第38回日本分子生物学会年会, 第88回日本生化学会大会 合同大会)
Place of Presentation
神戸ポートアイランド, 神戸市
Year and Date
2015-12-01
Related Report
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[Presentation] v-Srcによるチロシンリン酸化を介した細胞周期進行異常と細胞周期抑制因子の増加.2015
Author(s)
本田拓也, 中山祐治, 添田修平, 阿部紘平, 森井真理子, 山口千尋, 鈴木 亘, 久保田 翔, 青山和正, 山口憲孝, 山口直人.
Organizer
BMB2015(第38回日本分子生物学会年会, 第88回日本生化学会大会 合同大会)
Place of Presentation
神戸ポートアイランド, 神戸市
Year and Date
2015-12-01
Related Report
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[Presentation] v-Srcによる細胞周期異常と細胞周期関連タンパク質の解析.2015
Author(s)
本田拓也, 中山祐治, 添田修平, 阿部紘平, 森井真理子, 山口千尋, 鈴木 亘, 久保田 翔, 青山和正, 山口憲孝, 山口直人.
Organizer
第14回次世代を担う若手ファーマ・バイオフォーラム2015
Place of Presentation
千葉大学 (千葉市)
Year and Date
2015-09-12
Related Report
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