Studies of roles of G proteins in integration of axon guidance signaling
Project/Area Number |
15K07928
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
|
Research Institution | Kyoto University |
Principal Investigator |
Negishi Manabu 京都大学, 生命科学研究科, 教授 (60201696)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | Ras / Rho / G protein / 神経 / 軸索 / 樹状突起 / スパイン / ガイダンス / R-Ras / BDNF / neuron / G-protein / axon / RasGRF / TC21 / M-Ras / afadin / spine / splicing / effector |
Outline of Final Research Achievements |
R-Ras subfamily small GTPases have essential roles in multiple phases of developments of neurons. We have examined the roles of TC21, a member of R-Ras subfamily, and we found that TC21 was specifically expressed in spines and promoted spine maturation through afadin, a downstream effector of TC21. We also examined the upstream of R-Ras for R-Ras-mediated axon outgrowth, and we found that RasGRF1 was a GEF for R-Ras and BDNF activated R-Ras through RasGRF1, promoting axon outgrowth.
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Report
(4 results)
Research Products
(6 results)