| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Mutation of RABL2 and CEP19 genes are known to cause male infertility and morbid obesity, but its molecular mechanism is unknown. In this study, I studied the function of RABL2 and CEP19 involved in primary cilium formation. As a result, I found that RABL2 forms a complex with CEP19 and localizes at the basal body of primary cilia. When RABL2 is converted to GTP-bound form by guanine nucleotide exchange factor, it dissociates from CEP19 and transiently interacts with IFT-B complex via IFT74-IFT81 dimer. These results indicate that RABL2 regulates the entry of the IFT complex into primary cilium.
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