Development of an antibacterial activity enhancer that restores lost antibacterial activity
Project/Area Number |
15K07932
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Hiroshima University (2016-2017) Okayama University (2015) |
Principal Investigator |
Kuroda Teruo 広島大学, 医歯薬保健学研究科(薬), 教授 (80304327)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | topoisomerase / vancomycin / キノロン / バンコマイシン / MRSA / VRE / ペプチドグリカン |
Outline of Final Research Achievements |
The action mechanism of compound K on MRSA and VRE was investigated. Compound K inhibited topoisomerase IV of Staphylococcus aureus. However, this action mechanism was different from both ciprofloxacin and novobiocin, already known inhibitors of topoisomerase IV. Compound K also showed the combined effect with vancomycin. Expression of vancomycin resistant cluster genes was not inhibited with compound K, and exposure to compound K restored D-alanyl-D-alanine in VRE cells.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Action mechanism of 6, 6'-dihydroxythiobinupharidine from Nuphar japonicum, which showed anti-MRSA and anti-VRE activities.2015
Author(s)
Okamura S, Nishiyama E, Yamazaki T, Otsuka N, Taniguchi S, Ogawa W, Hatano T, Tsuchiya T, Kuroda T.
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Journal Title
Biochim Biophys Acta. (General Subjects)
Volume: 1850
Issue: 6
Pages: 1245-1252
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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