| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
It is known that TGF-beta is involved in carcinogenesis as a growth factor, but also has the effect of promoting malignancy of cancer. However, how these contradictory physiological effects are controlled remains unclear. In this study, we found that methyltransferase SET8 is one Smad cofactor that mediates its action. It also revealed that the tumor suppressor gene p53 is a cofactor that follows up the cancer suppressive action of TGF-beta.
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