The novel roles of O-glycans in hypothalamus-pituitary axis

• Project/Area Number: 15K07954
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: Nakayama Yoshiaki 神戸薬科大学, 薬学部, 講師 (40512455)
• Co-Investigator(Kenkyū-buntansha): 小西 守周 神戸薬科大学, 薬学部, 教授 (00322165) ; 黒坂 光 京都産業大学, 総合生命科学部, 教授 (90186536) ; 加藤 啓子 京都産業大学, 総合生命科学部, 教授 (90252684)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: プロラクチン / ドーパミン / 成長ホルモン / 下垂体 / 下垂体ホルモン / 視床下部 / 糖転移酵素 / ドーパミン作動性神経 / ノックアウトマウス / トランスジェニックマウス

Outline of Final Research Achievements

The secretion of the anterior pituitary hormone such as growth hormone and prolactin is strictly controlled by the endocrine signal from the hypothalamus. The elucidation of the pituitary control mechanisms is an important medical interest because it leads to the elucidation of the cause of intractable diseases caused by abnormal secretion of the pituitary anterior lobe hormone and the development of therapeutic methods. In this study, we found that Galnt17 plays an important role in maintaining the function of dopamine nerve projecting from the midbrain ventral to the striatum through analysis of Galnt17 mutant mice and others.

Research Products

• [Presentation] Galnt17/Wbscr17 knockout mice shows decreased growth and hyperplolactinemia (2015)
  • Author(s): Yoshiaki Nakayama, Keiko Kato, Naosuke Nakmura, Morichika Konishi, Akira Kurosaka
  • Organizer: Glyco2015
  • Place of Presentation: クロアチア、スプリト
  • Year and Date: 2015-09-15
  • Int'l Joint Research