Role of zinc and zinc transporters in the progression of breast cancers
| Project/Area Number |
15K07955
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 亜鉛トランスポーター / 亜鉛 / 乳がん / 悪性化進展 / Bcl-2 / YC137 / 細胞死 / オートファジー / タモキシフェン / Bcl-2阻害剤 / ストレス応答 |
|---|
| Outline of Final Research Achievements |
Zinc and zinc transporters are key molecules in malignant progression and might lead to novel strategies for the diagnosis and therapy of breast cancer. In this study, we elucidated the novel mechanism underlying estrogen receptor-positive human breast cancer progression involving zinc and zinc transporters (ZIP6). We also demonstrated that the efficacy of anti-breast cancer drugs was controlled by the regulation of zinc action through ZIP6 without the damage to normal cellular functions. Therefore, we propose to provide novel strategies for therapy of breast cancer using zinc network.
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Report
(4 results)
Research Products
(70 results)
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[Journal Article] Poly(ADP-ribose) Polymerase Inhibitors Activate the p53 Signaling Pathway in Neural Stem/Progenitor Cells.2017
Author(s)
Okuda, A., Kurokawa, S., Takehashi, M., Maeda, A., Fukuda, K., Kubo, Y., Nogusa, H., Takatani-Nakase, T., Okuda, S., Ueda, K., Tanaka, S.
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Journal Title
BMC Neurosci.
Volume: 18
Issue: 1
Pages: 14-14
DOI
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Peer Reviewed / Open Access
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[Presentation] Effective intracellular delivery based on biofunctional peptide-modified exosomes2016
Author(s)
Ikuhiko Nakase, Kosuke Noguchi, Natsumi Ueno, Miku Katayama, Nahoko Bailey Kobayashi, Tomoka Takatani-Nakase, Tetsuhiko Yoshida, Ikuo Fujii, and Shiroh Futaki
Organizer
34th European Peptide Symposium, 8th International Symposium 2016
Place of Presentation
Leipzig, Germany
Year and Date
2016-09-09
Related Report
Int'l Joint Research
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[Presentation] Effects of gefitinib on mitochondrial functionality2016
Author(s)
Tomoya Takenaka, Miku Katayama, Tomoka Takatani-Nakase, Ikuo Fujii, Susumu S. Kobayashi, and Ikuhiko Nakase
Organizer
The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics
Place of Presentation
京都府京都市
Year and Date
2016-06-24
Related Report
Int'l Joint Research
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[Book] 薬の生体内運命2017
Author(s)
丸山一雄
Total Pages
246
Publisher
ネオメディカル
ISBN
9784904634219
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