| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Mucosal humoral immunity in respiratory tract is a major defense system against influenza virus infection. The mucosal IgA regulation in small intestine is well studied, however, less is known of mechanism of anti-virus IgA induction in respiratory tract. Here, we showed the secretion of IL-6 and IFN-g mediated by the viral replication in lung was critical for anti-virus IgA induction. Our experiments using Bcl6 deficient mice, which does not develop Tfh cells and germinal center B cells, revealed that Tfh cells and germinal centers were dispensable for the anti-virus IgA induction in lung. Our finding give the informative insight for development of novel mucosal anti-influenza vaccines.
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