The mechanism of anti-viral IgA production in respiratory tract
Project/Area Number |
15K07958
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
|
Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Miyauchi Kosuke 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 副チームリーダー (50619856)
|
Co-Investigator(Renkei-kenkyūsha) |
KUBO Masato 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー (40277281)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | インフルエンザウイルス / IgA / 中和抗体 / サイトカイン / Influenza virus / Th1 / Lung / Tfh |
Outline of Final Research Achievements |
Mucosal humoral immunity in respiratory tract is a major defense system against influenza virus infection. The mucosal IgA regulation in small intestine is well studied, however, less is known of mechanism of anti-virus IgA induction in respiratory tract. Here, we showed the secretion of IL-6 and IFN-g mediated by the viral replication in lung was critical for anti-virus IgA induction. Our experiments using Bcl6 deficient mice, which does not develop Tfh cells and germinal center B cells, revealed that Tfh cells and germinal centers were dispensable for the anti-virus IgA induction in lung. Our finding give the informative insight for development of novel mucosal anti-influenza vaccines.
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Report
(4 results)
Research Products
(4 results)