| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Recent genetic studies have revealed that individual sPLA2s, which show distinct tissue distributions and substrate preferences, participate in diverse biological events in response to given microenvironmental cues. However, the regulatory roles of sPLA2s in metabolic disorders are not well understood. In this study, I aim to obtain new insights into novel regulatory mechanisms for metabolic diseases by sPLA2-driven extracellular phospholipid metabolism. We found that (1) sPLA2-IID contributes to metabolic health by mobilizing polyunsaturated fatty acids in white adipose tissue; (2) ablation of sPLA2-III in epidermis ameliorates metabolic syndrome; (3) sPLA2-X, which is highly expressed in the colon epithelium plays a role in amelioration of metabolic syndrome.
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