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Novel regulatory mechanism for metabolic syndrome based on extracellular phospholipid metabolism.

Research Project

Project/Area Number 15K07959
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionThe University of Tokyo (2017)
Tokyo Metropolitan Institute of Medical Science (2015-2016)

Principal Investigator

Sato Hiroyasu  東京大学, 大学院医学系研究科(医学部), 特任助教 (50546629)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsメタボリックシンドローム / リン脂質代謝 / ホスホリパーゼA2 / 脂肪酸 / 脂肪細胞ベージュ化 / エネルギー代謝 / 分泌型ホスホリパーゼA2 / 慢性炎症 / 分泌性ホスホリパーゼA2 / 高度不飽和脂肪酸 / マクロファージ
Outline of Final Research Achievements

Recent genetic studies have revealed that individual sPLA2s, which show distinct tissue distributions and substrate preferences, participate in diverse biological events in response to given microenvironmental cues. However, the regulatory roles of sPLA2s in metabolic disorders are not well understood. In this study, I aim to obtain new insights into novel regulatory mechanisms for metabolic diseases by sPLA2-driven extracellular phospholipid metabolism. We found that (1) sPLA2-IID contributes to metabolic health by mobilizing polyunsaturated fatty acids in white adipose tissue; (2) ablation of sPLA2-III in epidermis ameliorates metabolic syndrome; (3) sPLA2-X, which is highly expressed in the colon epithelium plays a role in amelioration of metabolic syndrome.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (9 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] University of Washington(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Washington(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] University of Washington(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Secreted Phospholipase A2 Specificity on Natural Membrane Phospholipids2017

    • Author(s)
      Yamamoto K, Miki Y, Sato H, Murase R, Taketomi Y, Murakami M
    • Journal Title

      Methods Enzymol

      Volume: 583 Pages: 101-117

    • DOI

      10.1016/bs.mie.2016.09.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical role for cytosolic group IVA phospholipase A2 in early adipocyte differentiation and obesity.2016

    • Author(s)
      Pena L, Meana C, Astudillo AM, Lorden G, Valdearcos M, Sato H, Murakami M, Balsinde J, Balboa MA.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1861 Issue: 9 Pages: 1083-1095

    • DOI

      10.1016/j.bbalip.2016.06.004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Expression and Function of Group IIE Phospholipase A2 in Mouse Skin2016

    • Author(s)
      Yamamoto K, Miki Y, Sato H, Nishito Y, Gelb MH, Taketomi Y, Murakami M
    • Journal Title

      J Biol Chem

      Volume: 291(30) Issue: 30 Pages: 15602-13

    • DOI

      10.1074/jbc.m116.734657

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Roles of the Secreted Phospholipase A2 Gene Family in Immunology2016

    • Author(s)
      Murakami M, Yamamoto K, Miki Y, Murase R, Sato H, Taketomi Y
    • Journal Title

      Adv Immunol

      Volume: 132 Pages: 91-134

    • DOI

      10.1016/bs.ai.2016.05.001

    • ISBN
      9780128047972
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolic regulation by secreted phospholipase A2.2016

    • Author(s)
      Sato H, Taketomi Y, Murakami M.
    • Journal Title

      Inflamm Regener.

      Volume: 36 Issue: 1 Pages: 1-7

    • DOI

      10.1186/s41232-016-0012-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.2016

    • Author(s)
      Murase R, Sato H, Yamamoto K, Ushida A, Nishito Y, Ikeda K, Kobayashi T, Yamamoto T, Taketomi Y, Murakami M.
    • Journal Title

      J Biol Chem.

      Volume: 291 Issue: 13 Pages: 6895-6911

    • DOI

      10.1074/jbc.m116.715672

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Specificity of secreted phospholipase A2s for natural membrane phospholipid.2016

    • Author(s)
      Yamamoto K, Miki Y, Sato H, Murase R, Taketomi Y, Murakami M.
    • Journal Title

      Methods Enztmol

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunological regulation by secreted phospholipase A22016

    • Author(s)
      Murakami M, Yamamoto K, Miki Y, Murase R, Sato H, Taketomi Y.
    • Journal Title

      Adv Immunol

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Metabolic regulation by secreted phospholipase A22016

    • Author(s)
      Murakami M, Taketomi Y, Sato H.
    • Journal Title

      Inflame Regener

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
  • [Presentation] 白色脂肪細胞のベージュ化に関わる Thermogenic sPLA2の同定2018

    • Author(s)
      佐藤弘泰、武富芳隆、三木寿美、 村上誠
    • Organizer
      第12回炎症・脂質代謝・メタボリサーチフォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脂肪細胞のベージュ化に関わるsPLA2の同定2017

    • Author(s)
      佐藤弘泰、武富芳隆、三木寿美、 村上誠
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] IID型分泌性ホスホリパーゼA2はメタボリックシンドロームの新規抑制因子である.2016

    • Author(s)
      佐藤弘泰, 牛田絢子, 武富芳隆, 三木寿美, 村上誠.
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター (宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] III型分泌性ホスホリパーゼA2は動脈硬化の新規増悪因子である.2016

    • Author(s)
      武富芳隆, 宮崎拓郎, 佐藤弘泰, 三木寿美, 村上誠.
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター (宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 皮膚の恒常性と病態における二種のsPLA2の発現と機能.2016

    • Author(s)
      山本圭, 三木寿美, 佐藤弘泰, 武富芳隆, 村上誠.
    • Organizer
      第58回日本脂質生化学会大会
    • Place of Presentation
      にぎわい交流館AU(あう)(秋田県秋田市)
    • Year and Date
      2016-06-10
    • Related Report
      2016 Research-status Report
  • [Presentation] sPLA2を起点としたメタボリックシンドロームの新規制御機構2015

    • Author(s)
      佐藤弘泰, 武富芳隆, 村上誠.
    • Organizer
      第14回ホスファチジルセリン研究会
    • Place of Presentation
      早稲田大学日本橋キャンパス 大ホール(コレド日本橋5階) (東京都千代田区)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] Annual Review 糖尿病・代謝・内分泌 20162016

    • Author(s)
      佐藤 弘泰, 村上 誠
    • Total Pages
      10
    • Publisher
      中外医学社
    • Related Report
      2015 Research-status Report
  • [Remarks] 東京都医学総合研究所 脂質代謝プロジェクト (村上研究室)

    • URL

      http://www.igakuken.or.jp/lipid/index_japanese.html

    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2022-06-06  

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