Novel regulatory mechanism for metabolic syndrome based on extracellular phospholipid metabolism.
Project/Area Number |
15K07959
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | The University of Tokyo (2017) Tokyo Metropolitan Institute of Medical Science (2015-2016) |
Principal Investigator |
Sato Hiroyasu 東京大学, 大学院医学系研究科(医学部), 特任助教 (50546629)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | メタボリックシンドローム / リン脂質代謝 / ホスホリパーゼA2 / 脂肪酸 / 脂肪細胞ベージュ化 / エネルギー代謝 / 分泌型ホスホリパーゼA2 / 慢性炎症 / 分泌性ホスホリパーゼA2 / 高度不飽和脂肪酸 / マクロファージ |
Outline of Final Research Achievements |
Recent genetic studies have revealed that individual sPLA2s, which show distinct tissue distributions and substrate preferences, participate in diverse biological events in response to given microenvironmental cues. However, the regulatory roles of sPLA2s in metabolic disorders are not well understood. In this study, I aim to obtain new insights into novel regulatory mechanisms for metabolic diseases by sPLA2-driven extracellular phospholipid metabolism. We found that (1) sPLA2-IID contributes to metabolic health by mobilizing polyunsaturated fatty acids in white adipose tissue; (2) ablation of sPLA2-III in epidermis ameliorates metabolic syndrome; (3) sPLA2-X, which is highly expressed in the colon epithelium plays a role in amelioration of metabolic syndrome.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility.2016
Author(s)
Murase R, Sato H, Yamamoto K, Ushida A, Nishito Y, Ikeda K, Kobayashi T, Yamamoto T, Taketomi Y, Murakami M.
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Journal Title
J Biol Chem.
Volume: 291
Issue: 13
Pages: 6895-6911
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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