| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We have previously isolated DDC from green perilla leaves as an activator of the Nrf2-ARE pathway. Here, we showed the neuroprotective effect of DDC on PD models in vivo and in vitro. In a 6-OHDA-induced Parkinson's disease mouse model, intracerebral administration of DDC suppressed the dopaminergic neuronal loss and behavioral dysfunction. In primary mesencephalic cultures, DDC showed a protective effect against 6-OHDA-induced dopaminergic neuronal death. These results suggest that DDC prevents dopaminergic neurons from oxidative stress.
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