Creation of therapeutic and preventive strategies for neurological diseases by low molecular weight functional molecules and compounds derived from foods
| Project/Area Number |
15K07965
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
Toshiaki Kume 京都大学, 薬学研究科, 准教授 (10303843)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経保護 / 脳疾患 / 抗酸化 |
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| Outline of Final Research Achievements |
We have previously isolated DDC from green perilla leaves as an activator of the Nrf2-ARE pathway. Here, we showed the neuroprotective effect of DDC on PD models in vivo and in vitro. In a 6-OHDA-induced Parkinson's disease mouse model, intracerebral administration of DDC suppressed the dopaminergic neuronal loss and behavioral dysfunction. In primary mesencephalic cultures, DDC showed a protective effect against 6-OHDA-induced dopaminergic neuronal death. These results suggest that DDC prevents dopaminergic neurons from oxidative stress.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 82017
Author(s)
Okuda M, Fujita Y, Hijikuro I, Wada M, Uemura T, Kobayashi Y, Waku T, Tanaka N, Nishimoto T, Izumi Y, Kume T, Akaike A, Takahashi T, Sugimoto H.
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Journal Title
Journal of Alzheimer's Disease
Volume: 59
Pages: 313-328
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Monoclonal antibody with conformation specificity for a toxic conformer of amyloid beta42 and its application toward the Alzheimer’s disease diagnosis2016
Author(s)
Kazuma Murakami, Maki Tokuda, Takashi Suzuki, Yumi Irie, Mizuho Hanaki, Naotaka Izuo, Yoko Monobe, Ken-ichi Akagi, Ryotaro Ishii, Harutsugu Tatebe, Takahiko Tokuda, Masahiro Maeda, Toshiaki Kume, Takahiko Shimizu, Kazuhiro Irie
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Journal Title
Scientific Reports
Volume: 6
Pages: 29038-29038
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] 10-Oxo-trans-11-octadecenoic acid generated from linoleic acid by a gut lactic acid bacterium Lactobacillus plantarum is cytoprotective against oxidative stress.2016
Author(s)
Furumoto, H., T. Nanthirudjanar, T. Kume, Y. Izumi, S.B. Park, N. Kitamura, S. Kishino, J. Ogawa, T. Hirata, T. Sugawara
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Journal Title
Toxicol Appl Pharmacol
Volume: 296
Pages: 1-9
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Compensatory role of the Nrf2-ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity.2015
Author(s)
Izumi, Y., Yamamoto, N., Matsushima, S., Yamamoto, T., Takada-Takatori, Y., Akaike, A., and Kume, T
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Journal Title
J Pharmacol Sci.
Volume: 129
Pages: 150-159
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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