Drug development for intractable epilepsy by targeting lactate dehydrogenase
| Project/Area Number |
15K07966
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pharmacology in pharmacy
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
Inoue Tsuyoshi 岡山大学, 医歯薬学総合研究科, 准教授 (40370134)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 難治性てんかん / ケトン食療法 / 乳酸脱水素酵素 / スチリペントール / ケトン体 / 電位依存性カルシウムチャネル / 興奮性シナプス / アセチルコリン / 抗てんかん剤開発 / グルタミン酸作動性シナプス |
|---|
| Outline of Final Research Achievements |
We addressed the following three issues in this study, in order to clarify the mechanisms that control "drug-resistant intractable epilepsy" and to develop new antiepileptic drugs based on the mechanisms. First, we focused on "ketogenic diet treatment" that is effective for the drug-resistant epilepsy, and identified a lactate dehydrogenase inhibitor that suppresses seizures in vivo. Second, we found that acetoacetate (a ketogenic diet-derived metabolite) inhibits voltage-dependent calcium channels, and then identified an acetoacetate analog that suppresses seizures in vivo. Finally, we found that acetylcholine is involved in the seizure control in a mouse model of drug-resistant epilepsy
|
Report
(4 results)
Research Products
(9 results)
