| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We addressed the following three issues in this study, in order to clarify the mechanisms that control "drug-resistant intractable epilepsy" and to develop new antiepileptic drugs based on the mechanisms. First, we focused on "ketogenic diet treatment" that is effective for the drug-resistant epilepsy, and identified a lactate dehydrogenase inhibitor that suppresses seizures in vivo. Second, we found that acetoacetate (a ketogenic diet-derived metabolite) inhibits voltage-dependent calcium channels, and then identified an acetoacetate analog that suppresses seizures in vivo. Finally, we found that acetylcholine is involved in the seizure control in a mouse model of drug-resistant epilepsy
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