Significance of the change in the expression levels of microRNAs in neurodegenerative diseases in the retina
| Project/Area Number |
15K07971
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pharmacology in pharmacy
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 薬理学 / 脳神経疾患 / 緑内障 / 網膜色素変性症 / microRNA / アポトーシス / 網膜 / 神経細胞死 |
|---|
| Outline of Final Research Achievements |
Intravitreal injection of NMDA induced upregulation of miR-29b and downregulation of miR-124 in the retina of C57BL/6J mice. Pre-treatment with miR-29b inhibitor and miR-124 mimic protected against the NMDA-induced retinal injury.
In nmf363 mice, an animal model of retinitis pigmentosa, the expression level of miR-133a decreased with age. Subretinal injection of miR-133a mimic at postnatal day 15 significantly reduced photoreceptor degeneration at postnatal day 25.
These data suggest that progress of narrowing of visual field in the retinal neurodegenerative diseases could be supressed by alternation of the expression levels of microRNAs.
|
Report
(4 results)
Research Products
(33 results)
