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Selective elimination of tumor clones of primary myelofibrosis based on drug repositioning

Research Project

Project/Area Number 15K07972
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pharmacology in pharmacy
Research InstitutionJuntendo University

Principal Investigator

Gotoh Akihiko  順天堂大学, 医学部, 先任准教授 (00297293)

Co-Investigator(Kenkyū-buntansha) 小松 則夫  順天堂大学, 医学部, 教授 (50186798)
宮澤 啓介  東京医科大学, 医学部, 主任教授 (50209897)
Research Collaborator ARAKI Marito  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsprimary myelofibrosis / ruxolitinib / macrolide / thrombopoietin / calreticulin / myelofibrosis / thrombopietin / autophagy / 原発性骨髄線維症 / オートファジー / ルキソリチニブ / マクロライド
Outline of Final Research Achievements

A mutant gene of calreticulin (CALR), which is a major driver mutation for primary myelofibrosis (PMF), was introduced into thrombopoietin (TPO) -dependent cell lines to obtain stable mutant transgenic lines. The mutant transgenic strain acquired TPO-independent growth ability and was considered to reflect the neoplastic character of PMF. Although clarithromycin (CAM) alone does not show a suppressive effect on CALR-mutated cells, the combination with ruxolitinib (RUX) enhanced the cytostatic action of RUX. The combination with RUX by drug repositioning of the macrolides with established safety was considered as a promising option to enhance the clinical effect of RUX.

Academic Significance and Societal Importance of the Research Achievements

原発性骨髄線維症(PMF)は予後不良な難治性造血器腫瘍である。JAK2 阻害薬ルキソリチニブはPMFに対して脾腫縮小、全身症状改善などの高い臨床効果を示すが腫瘍クローン減少効果は低い。本研究では安全性が確立しているマクロライドのオートファジー阻害活性に注目し、ルキソリチニブとの併用により相乗的にPMFのモデル細胞が抑制されることを示した。この結果はマクロライドのドラッグ・リポジショニングにより、PMFに対して安全性と医療経済効果の両立した分子標的療法を確立する可能性を期待させるものと考えられる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (55 results)

All 2019 2018 2017 2016 2015

All Journal Article (30 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 25 results,  Open Access: 13 results,  Acknowledgement Compliant: 3 results) Presentation (23 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] Evidence for prevention of renal dysfunction associated with primary myelofibrosis by cytoreductive therapy2019

    • Author(s)
      Fukuda Yasutaka、Araki Marito、Yamamoto Kouji、Morishita Soji、Inano Tadaaki、Misawa Kyohei、Ochiai Tomonori、Edahiro Yoko、Imai Misa、Yasuda Hajime、Gotoh Akihiko、Ohsaka Akimichi、Komatsu Norio
    • Journal Title

      Haematologica

      Volume: 印刷中 Issue: 11 Pages: e506-e509

    • DOI

      10.3324/haematol.2018.208876

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] round-table talk Meet the MPN experts in EHA フィラデルフィア染色体陰性MPNの診断・治療の課題と将来展望2018

    • Author(s)
      小松則夫, Kiladjan JJ, Roy L, Shih L-Y, Chen C-C, 後藤明彦
    • Journal Title

      血液フロンティア

      Volume: 28 Issue: 2 Pages: 256-267

    • DOI

      10.20837/5201802256

    • ISSN
      1344-6940
    • Year and Date
      2018-01-30
    • Related Report
      2017 Research-status Report
  • [Journal Article] Transfusion independence achieved with pomalidomide therapy in a patient with primary myelofibrosis2018

    • Author(s)
      枝廣 陽子, 後藤 明彦, 稲野 資明, 筒井 深雪, 築根 豊, 安田 肇, 小松 則夫
    • Journal Title

      Rinsho Ketsueki

      Volume: 59 Issue: 3 Pages: 323-325

    • DOI

      10.11406/rinketsu.59.323

    • NAID

      130006627427

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutational subtypes of JAK2 and CALR correlate with different clinical features in Japanese patients with myeloproliferative neoplasms.2018

    • Author(s)
      Misawa K, Yasuda H, Araki M, Ochiai T, Morishita S, Shirane S, Edahiro Y, Gotoh A, Ohsaka A, Komatsu N.
    • Journal Title

      Int J Hematol

      Volume: 印刷中 Issue: 6 Pages: 673-680

    • DOI

      10.1007/s12185-018-2421-7

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The 2014 BCSH criteria and the 2016 WHO criteria for essential thrombocythemia: A comparison in a large-scale cohort.2018

    • Author(s)
      Ochiai T, Yasuda H, Araki M, Misawa K, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Gotoh A, Ohsaka A, Komatsu N.
    • Journal Title

      Eur J Haematol

      Volume: 印刷中 Issue: 6 Pages: 544-549

    • DOI

      10.1111/ejh.13041

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Designing an effective drug combination for ER stress loading in cancer therapy using a real-time monitoring system2018

    • Author(s)
      Kazama H, Hiramoto M, Miyahara K, Takano N, Miyazawa K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: - Issue: 1 Pages: 286-292

    • DOI

      10.1016/j.bbrc.2018.05.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis.2018

    • Author(s)
      Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, Hino H, Kikuchi H, Takano N, Hiramoto M, Tsukahara K, Miyazawa K.
    • Journal Title

      Int J Oncol.

      Volume: 52 Pages: 1165-1177

    • DOI

      10.3892/ijo.2018.4282

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutant molecular chaperone activates cytokine receptor as a homomultimer2018

    • Author(s)
      Araki Marito、Komatsu Norio
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 81 Pages: 35201-35202

    • DOI

      10.18632/oncotarget.26221

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple Placental Infarcts in a Pregnant Woman with Essential Thrombocythemia2018

    • Author(s)
      Edahiro Yoko、Ando Jun、Suzuki Toshifumi、Fukumura Yuki、Masuda Azuchi、Sakayori Shiori、Takeda Jun、Maruyama Yojiro、Makino Shintaro、Itakura Atsuo、Komatsu Norio
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 24 Pages: 3647-3650

    • DOI

      10.2169/internalmedicine.1311-18

    • NAID

      130007531198

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation2018

    • Author(s)
      Araki Marito、Yang Yinjie、Imai Misa、Mizukami Yoshihisa、Kihara Yoshihiko、Sunami Yoshitaka、Masubuchi Nami、Edahiro Yoko、Hironaka Yumi、Osaga Satoshi、Ohsaka Akimichi、Komatsu Norio
    • Journal Title

      Leukemia

      Volume: 33 Issue: 1 Pages: 122-131

    • DOI

      10.1038/s41375-018-0181-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations2018

    • Author(s)
      Hiraku Takei, Yoko Edahiro, Shuichi Mano, Nami Masubuchi, Yoshihsa Mizukami, Misa Imai, Soji Morishita, Kyohei Misawa, Tomonori Ochiai, Satoshi Tsuneda, Hiroshi Endo, Sou Nakamura, Koji Eto, Akimichi Ohsaka, Marito Araki, Norio Komatsu
    • Journal Title

      British Journal of Haematology

      Volume: 印刷中 Issue: 6 Pages: 791-802

    • DOI

      10.1111/bjh.15266

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of ruxolitinib therapy on the quality of life of Japanese patients with myelofibrosis.2018

    • Author(s)
      Oritani K, Ohishi K, Okamoto S, Kirito K, Komatsu N, Tauchi T, Handa H, Saito S, Takenaka K, Shimoda K, Okada H, Amagasaki T, Wakase S, Shimozuma K, Akashi K
    • Journal Title

      Curr Med Res Opin

      Volume: 34 Issue: 3 Pages: 531-537

    • DOI

      10.1080/03007995.2017.1415874

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Meet the MPN experts in EHA フィラデルフィア染色体陰性MPNの診断・治療の課題と将来展望 MPNを巡る臨床的課題と将来展望を語る(座談会)2018

    • Author(s)
      小松 則夫, Kiladjian Jean-Jacques, ROY Lydia, Shih Lee-Yung, Chen Chin-Cheng, 後藤 明彦
    • Journal Title

      血液フロンティア

      Volume: 28 Pages: 263-267

    • Related Report
      2018 Annual Research Report
  • [Journal Article] The 2016 WHO diagnostic criteria for polycythemia vera renders an accurate diagnosis to a broader range of patients including masked polycythemia vera: Comparison with the 2008 WHO diagnostic criteria.2017

    • Author(s)
      Misawa K, Yasuda H, Araki M, Ochiai T, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Gotoh A, Ohsaka A, Komatsu N.
    • Journal Title

      Am J Hematol

      Volume: 92 Issue: 7

    • DOI

      10.1002/ajh.24752

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 骨髄増殖性腫瘍(MPN)の分子病態と診断・治療のup-to-date】 Ph陰性MPNの予後・予後予測因子2017

    • Author(s)
      後藤明彦
    • Journal Title

      最新医学

      Volume: 72 Pages: 1565-1571

    • Related Report
      2017 Research-status Report
  • [Journal Article] Assessing the safety and efficacy of ruxolitinib in a multicenter, open-label study in Japanese patients with myelofibrosis.2017

    • Author(s)
      Komatsu N, Kirito K, Shimoda K, Ishikawa T, Ohishi K, Ohyashiki K, Takahashi N, Okada H, Amagasaki T, Yonezu T, Akashi K.
    • Journal Title

      Int J Hematol

      Volume: 105 Issue: 3 Pages: 309-317

    • DOI

      10.1007/s12185-016-2130-z

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Macrolide antibiotics exhibit cytotoxiceffect under amino acid-depleted culture condition by blocking autophagy flux in head and neck squamous cell carcinoma cell lines.2016

    • Author(s)
      Hirasawa K, Moriya S, Miyahara K, Kazama H, Hirota A, Takemura J, Abe A, Inazu M, Hiramoto M, Tsukahara K, Miyazawa K.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 12 Pages: 1848-1858

    • DOI

      10.1371/journal.pone.0164529

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines.2016

    • Author(s)
      Miyahara K, Kazama H, Kokuba H, Komatsu S, Hirota A, Takemura J, Hirasawa K,Moriya S, Abe A, Hiramoto M, Ishikawa T, Miyazawa K.
    • Journal Title

      Int J Oncol.

      Volume: 49 Issue: 5 Pages: 1848-1858

    • DOI

      10.3892/ijo.2016.3673

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Gene mutations in myeloproliferative neoplasms2016

    • Author(s)
      荒木 真理, 森下 総司, 小松 則夫
    • Journal Title

      Rinsho Ketsueki

      Volume: 57 Issue: 12 Pages: 2526-2534

    • DOI

      10.11406/rinketsu.57.2526

    • NAID

      130005286786

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 骨髄増殖性腫瘍をひき起こす変異型calreticulinによるTPO受容体の活性化機構2016

    • Author(s)
      今井 美沙, 荒木 真理人, 森下 総司, 小松 則夫
    • Journal Title

      血液内科

      Volume: 73 Pages: 789-793

    • NAID

      40021031814

    • Related Report
      2016 Research-status Report
  • [Journal Article] 診断における遺伝子変異の意義と問題点2016

    • Author(s)
      小松 則夫
    • Journal Title

      日本検査血液学会雑誌

      Volume: 17 Pages: 347-353

    • Related Report
      2016 Research-status Report
  • [Journal Article] Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines.2016

    • Author(s)
      Mukai S, Moriya S, Hiramoto M, Kazama H, Kokuba H, Che XF, Yokoyama T, Sakamoto S, Sugawara A, Sunazuka T, Omura S, Handa H, Itoi T, Miyazawa K.
    • Journal Title

      Int J Oncol

      Volume: 48 Issue: 1 Pages: 45-54

    • DOI

      10.3892/ijo.2015.3237

    • NAID

      120005845877

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms.2016

    • Author(s)
      Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N
    • Journal Title

      Blood

      Volume: 127 Issue: 10 Pages: 1307-16

    • DOI

      10.1182/blood-2015-09-671172

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress-mediated cell death in multiple myeloma cells.2015

    • Author(s)
      Moriya S, Komatsu S, Yamasaki K, Kawai Y, Kokuba H, Hirota A, Che XF, Inazu M, Gotoh A, Hiramoto M, Miyazawa K
    • Journal Title

      Int J Oncol.

      Volume: Feb;46(2) Issue: 2 Pages: 474-86

    • DOI

      10.3892/ijo.2014.2773

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Usefulness of BCSH Criteria for Diagnosing Japanese Polycythemia Vera -Comparative Analysis with WHO 2008 Criteria-2015

    • Author(s)
      Yahata Y, Gotoh A, Komatsu N
    • Journal Title

      Juntendo Medical Journal

      Volume: 61 Pages: 287-293

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reactivation of hepatitis B virus during treatment with hydroxyurea in an elderly patient with essential thrombocythemia.2015

    • Author(s)
      Watanabe N, Yasuda H, Aota Y, Ando J, Aoyama T, Tanaka M, Gotoh A, Komatsu N.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 15 Issue: 6 Pages: 812-3

    • DOI

      10.1111/ggi.12461

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells.2015

    • Author(s)
      Sugita S, Ito K, Yamashiro Y, Moriya S, Che XF, Yokoyama T, Hiramoto M, Miyazawa K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: Apr 7 Issue: 1 Pages: 28-34

    • DOI

      10.1016/j.bbrc.2015.03.162

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Melting curve analysis after T allele enrichment (MelcaTle) as a highly sensitive and reliable method for detecting the JAK2V617F mutation.2015

    • Author(s)
      Morishita S, Takahashi K, Araki M, Hironaka Y, Sunami Y, Edahiro Y, Tsutsui M, Ohsaka A, Tsuneda S, Komatsu N.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: e0122003-e0122003

    • DOI

      10.1371/journal.pone.0122003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Consequences of the JAK2V617F allele burden for the prediction of transformation into myelofibrosis from polycythemia vera and essential thrombocythemia.2015

    • Author(s)
      Shirane S, Araki M, Morishita S, Edahiro Y, Sunami Y, Hironaka Y, Noguchi M, Koike M, Sato E, Ohsaka A, Komatsu N.
    • Journal Title

      Int J Hematol

      Volume: 101 Issue: 2 Pages: 148-53

    • DOI

      10.1007/s12185-014-1721-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Current problems in the diagnosis of Philadelphia-negative myeloproliferative neoplasms in Japan2015

    • Author(s)
      白根脩一、荒木真理人、森下総司、枝廣陽子、大阪顯通、小松則夫
    • Journal Title

      Rinsho Ketsueki

      Volume: 56 Issue: 7 Pages: 877-882

    • DOI

      10.11406/rinketsu.56.877

    • NAID

      130005093120

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Copy number of JAK2V617 modulates human hematopoietic cell differentiation .2018

    • Author(s)
      Edahiro Y, Mano S, Takei H, Li L, Morishita S, Gotoh A, Tsuneta S, Osaka A, Araki M, Komatsu N
    • Organizer
      8th International Conference on Myeloproliferative Neoplasms
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical and molecular features of patients with triple-negative essential thrombocythemia.2018

    • Author(s)
      Inano T, Araki M, Fukuda Y, Morishita S, Ochiai T, Misawa K, Ito M, Yamamoto K, Yang Y, Taguchi T, Edahiro Y, Imai M, Gotoh A, Osaka A, Komatsu N.
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cytoreductive therapy prevents worsening of renal function in patients with primary myelofibrosis.2018

    • Author(s)
      Fukuda Y, Araki M, Imamoto K, Morishita S, Inano T, Misawa K, Ochiai T, Edahiro Y, Imai M, Gotoh A, Osaka A, Komatsu N.
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Interferon therapy for pregnant patients with myeloproliferative neoplasms.2018

    • Author(s)
      Edahiro Y, Gotoh A, Ando J, Tsutsui M, Morishita S, Osaka A, Komatsu N.
    • Organizer
      第80回日本血液学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Myeloproliferative neoplasm with BCR-JAK2 fusion2017

    • Author(s)
      Tsutsui M, Gotoh , Morishita S, Araki M, Fukuda Y, Nitta H, Ando J, Komatsu N.
    • Organizer
      第79回日本血液学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Treatment for myelodysplastic syndrome: with a focus on the low-risk group2017

    • Author(s)
      Gotoh A
    • Organizer
      第79回日本血液学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Clinical characteristics of BCSH criteria defined PV and ET patients in Japan2016

    • Author(s)
      Ochiai M, Araki M, Misawa K, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Sunami Y, Goth A, Osaka A, Komatsu N
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Impact of mutations on efficacy of anagrelide in Japanese patients with essential thrombocythemia2016

    • Author(s)
      Tsutsui M, Gotoh, A Araki M, Morishita S, Komatsu N
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Evaluation of the dose and efficacy of ruxolitinib in Japanese patients with myelofibrosis2016

    • Author(s)
      Kirito K, Okamoto S, Shishi K, Tauchi T, Handa H, Saito S, Takenaka K, Shimoda K, Ogitani K, Komatsu N, Okada H, Amagasaki T, Suzuki K Yonezo T, Akashi K
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Differential clinical features by subtypes of Calreticulin mutation in myeloproliferative neoplasms2016

    • Author(s)
      Misawa K, Araki M, Ochiai T, Morishita S, Nudejima M, Hironaka Y, Shirane S, Edahiro Y, Sunami S, Gotoh A, Osaka A, Komatsu N
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Modeling MPN phenotypes in vitro by using iPSC harboring CALR ins5 mutation2016

    • Author(s)
      Takei T, Masubuchi N, Mano S, Araki M, Morishita S, Mizukami Y, Kan S, Edahiro Y, Sunami Y, Hironaka Y, Endo H, Nakamura S, Eto K, Osaka A, Komatsu N
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Mutant calreticulin activates the thrombopoietin receptor in myeloproliferative neoplasms2016

    • Author(s)
      Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Osaka A, Komatsu N
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Macrolides enhance bortezomib-induced cytotoxicity in myeloma cells co-cultured with stroma layer2016

    • Author(s)
      Morishita S, Kzazma H, Hiramoto M, Aizawa S, Sunazuka T, Handa H, Miyazawa K
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Cell surface localization of mutant calreticulin that induces myeloproliferative neoplasms (MONs)2016

    • Author(s)
      Masubuchi N, Araki M, Yang Y, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Osaka A, Komatsu N
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 骨髄増殖性腫瘍細胞において変異型Calreticulinはトロンボポエチン受容体と相互作用しJAK2を活性化する2016

    • Author(s)
      荒木 真理人, 小松 則夫
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] アミノ酸飢餓状態下で、マクロライド系抗菌薬はオートファジー阻害により頭頸部癌細胞株の細胞死を誘導する2016

    • Author(s)
      平澤 一浩, 森谷 昇太, 宮原 か奈, 平本 正樹, 塚原 清彰, 宮澤 啓介
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] ビノレルビンは乳癌細胞株においてアグリソーム形成を阻害することによりボルテゾミブ誘導性の細胞毒性を増強する2016

    • Author(s)
      宮原 か奈, 森谷 昇太, 小松 誠一郎, 平澤 一浩, 阿部 晃久, 平本 正樹, 石川 孝, 宮澤 啓介
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Activation of AP-1 By JAK2V617F through Induction and Stabilization of c-FOS2015

    • Author(s)
      Yoko Edahiro, Marito Araki, Yumi Hironaka, Yinjie Yang, Soji Morishita, Yoshitaka Sunami, Akimichi Ohsaka, Norio Komatsu
    • Organizer
      第57回米国血液学会議
    • Place of Presentation
      Orland,Florida, USA
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Assessing the Safety and Efficacy of Ruxolitinib in a Multicenter, Open-Label, Expanded-Access Study in Japanese Patients with Myelofibrosis (MF)2015

    • Author(s)
      Keita Kirito, Norio Komatsu, Kazuya Shimoda, Hikaru Okada, Taro Amagasaki, Toshio Yonezu, Koichi Akashi
    • Organizer
      第57回米国血液学会議
    • Place of Presentation
      Orland,Florida, USA
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Establishment of iPS cells from myeloproliferative neoplasms patients with CALR mutation2015

    • Author(s)
      竹井 拓, 森下 総司, 荒木 真理人, 水上 喜久, 枝廣 陽子, 角南 義孝, 弘中 由美, 津村 真知子, 常田 聡, 遠藤 大, 中村 壮, 江藤 浩之, 大坂 顯通, 小松 則夫
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢、ホテル金沢、金沢市アートホール、もてなしドーム(石川県、金沢市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Early disease onset of patients with triple-negative myeloproliferative neoplasms2015

    • Author(s)
      白根 脩一, 荒木 真理人, 森下 総司, 枝廣 陽子, 竹井 拓, 津村 真知子, 弘中 由美, 落合 友則, 三澤 恭平, 大坂 顯通, 小松 則夫
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢、ホテル金沢、金沢市アートホール、もてなしドーム(石川県、金沢市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] A highly specific method for detecting a single copy JAK2V617F mutation2015

    • Author(s)
      森下 総司, 荒木 真理人, 弘中 由美, 角南 義孝, 枝廣 陽子, 筒井 深雪, 大坂 顯通, 小松 則夫
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢、ホテル金沢、金沢市アートホール、もてなしドーム(石川県、金沢市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Trangeting autophagy with clarithromycin enhances gefitinib-induced cell death in non-small cell lung cancer cells2015

    • Author(s)
      森谷昇太、車暁芳、横山智央、平本正樹、宮澤啓介
    • Organizer
      第74回 日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県、名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Book] 病気がみえる vol.5 血液 骨髄系腫瘍2017

    • Author(s)
      後藤明彦 監修
    • Publisher
      メディックメディア
    • Related Report
      2016 Research-status Report
  • [Book] 骨髄線維症 小松則夫編 第3章 骨髄線維症の診断と予後 1.診断2016

    • Author(s)
      後藤明彦
    • Publisher
      医薬ジャーナル社
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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