Molecular mechanism underlying pathophysiological insulin secretion during early type 2 diabetes mellitus.
| Project/Area Number |
15K07973
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MITSUMOTO Asuka (KAIZAKI Asuka) 昭和大学, 薬学部, 講師 (70407443)
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| Research Collaborator |
ISHII Shunichi
TANAKA Maho
HAMAGUCHI Momoe
Ohno Sayuri
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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|---|
| Keywords | 高インスリン血症 / 酸化ストレス / TRPチャネル / 膵島 / 活性酸素 / TRPA1 / Nrf2 |
|---|
| Outline of Final Research Achievements |
Hyperinsulinemia often observed in the early type 2 diabetes mellitus has been shown to be associated with a higher risk of Alzheimer's disease and colorectal cancer. The present study focuses on characteristics of islet beta cells, which are susceptible to oxidative stress, and aims to clarify its pathophysiological significance.
The present study demonstrated that the redox-sensitive TRP channels activated by reactive oxygen species produced in cells in response to the glucose uptake may have a physiological role in fast-acting insulin secretion. On the other hand, it is suggested that electrophiles produced by sustained high blood glucose levels as well as hyperlipidemia induces persistent activation of the TRP channel, inducing pathological insulin secretion.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] The pharmacokinetics of mianserin suppositories for rectal administration in dogs and healthy volunteers: a pilot study.2016
Author(s)
Nawata S, Kohyama N, Uchida N, Numazawa S, Ohbayashi M, Kobayashi Y, Iwata M, Nakajima T, Saito H, Izuka A, Yamamoto T.
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Journal Title
J Pharm Health Care Sci
Volume: 2
Issue: 1
Pages: 12-12
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Three 25-NBOMe-type drugs, three other phenethylamine-type drugs (25I-NBMD, RH34 and escaline), eight cathinone derivatives and a phencyclidine analog MMXE, newly identified in ingredients of drug products before they were sold on the drug market.2016
Author(s)
Kaizaki-Mitsumoto A, Noguchi N, Yamaguchi S, Odanaka Y, Matsubayashi S, Kumamoto H, Fukuhara K, Funada M, Wada K, Numazawa S.
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Journal Title
Forensic Toxicol
Volume: 34
Issue: 1
Pages: 108-114
DOI
Related Report
Peer Reviewed
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[Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor.2016
Author(s)
Xu Z, Ohtaki H, Watanabe J, Miyamoto K, Murai N, Sasaki S, Matsumoto M, Hashimoto H, Hiraizumi Y, Numazawa S, Shioda S.
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Journal Title
Sci Rep
Volume: 6
Issue: 1
Pages: 22373-22373
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Book] トキシコロジー（第3版）2018
Author(s)
日本毒性学会教育委員会 編，沼澤聡 執筆
Total Pages
404
Publisher
朝倉書店
ISBN
9784254340310
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