Pharmacological and translational studies of centrally-acting peptide derivatives specialized in the delivery to the brain by the intranasal administration
Project/Area Number |
15K07974
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pharmacology in pharmacy
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Research Institution | Tokyo University of Science |
Principal Investigator |
Oka Jun-Ichiro 東京理科大学, 薬学部薬学科, 教授 (40134613)
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Co-Investigator(Kenkyū-buntansha) |
山下 親正 東京理科大学, 薬学部薬学科, 教授 (30622188)
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Co-Investigator(Renkei-kenkyūsha) |
HAMADA Sachie (SASAKI Sachie) 東京理科大学, 薬学部, ポストドクトラル研究員 (00399320)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 経鼻投与 / 中枢移行性 / GLP-2 / GLP-1 / Neuromedin U / Oxytocin / うつ病 / 認知症 |
Outline of Final Research Achievements |
The intranasally administered GLP-2 derivative containing cell-penetrating peptides and a penetration-accelerating sequence induced antidepressant-like effects in refractory depression model mice. Similarly, intranasally administered GLP-1, neuromedin U or oxytocin derivatives induced memory improving effects in amnesia model mice. These derivatives are probably delivered to the brain through the trigeminal nerve from the respiratory epithelium in the nasal mucosa. These results indicate that the derivatives may useful in the clinical treatment of psychiatric and neurological disorders by the intranasal administration.
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Report
(4 results)
Research Products
(45 results)
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[Presentation] 経鼻投与用GLP-2誘導体の中枢薬理作用2016
Author(s)
中村龍治、濱田幸恵、堀口道子、恒岡弥生、中尾優介、山下親正、岡淳一郎
Organizer
トランスレーショナルリサーチ(TR)センター第3回シンポジウム
Place of Presentation
東京理科大学葛飾キャンパス図書館大ホール (東京都葛飾区)
Year and Date
2016-01-23
Related Report
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[Presentation] 経鼻投与用中枢作用性ペプチド誘導体の作製と作用解析2015
Author(s)
岡淳一郎、濱田幸恵、堀口道子、恒岡弥生、中村龍治、中尾優介、山下親正
Organizer
トランスレーショナルリサーチ(TR)センター第2回シンポジウム
Place of Presentation
東京理科大学葛飾キャンパス図書館大ホール (東京都葛飾区)
Year and Date
2015-08-29
Related Report
Invited
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