Modulation of cough reflec byf tast 2 receptors

• Project/Area Number: 15K07976
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Hoshi University
• Principal Investigator: Kamei Junzo 星薬科大学, 薬学部, 教授 (40161236)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 苦味受容体 / 咳嗽反射 / 気道収縮 / ＲＡＲ / 鎮咳作用 / Ａδ線維 / RARｓ / デナトニウム / テルブタリン / モグイステイン / taste receptor type-2 / 咳受容体 / メサコリン

Outline of Final Research Achievements

There are at least two mechanisms for the development chronic coughs. One is the enhanced excitability of cough receptors which caused an atopic cough. Another is contraction of the airway smooth muscle which caused cough variant asthma COPD. The aim of this study is to elucidate the Taste 2 receptors (TAS2R) mediated-neuronal networks which involved in the modulation of the excitability of cough receptor by airway contraction. The results of this research suggest that TR2R receptor activation may inhibit the airway contraction-induced cough hypersensitivity through the ATP-sensitive K+ channels.

Research Products

• [Book] 咳の診かた、止めかた (2016)
  • Author(s): 亀井淳三
  • Total Pages: 247
  • Publisher: 羊土社