| Project/Area Number |
15K07979
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
FUJII TAKESHI 同志社女子大学, 薬学部, 教授 (80255380)
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| Co-Investigator(Kenkyū-buntansha) |
間下 雅士 同志社女子大学, 薬学部, 助教 (30738886)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWASHIMA KOICHIRO 北里大学, 薬学部, 客員教授 (70095008)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Acetylcholine / T cell / muscarinic receptor / naive T cell / Ca2+ / アセチルコリン / ムスカリン受容体 / T細胞 / カルシウム / サイトカイン / フローサイトメトリー / 制御性T細胞 / カルシウムシグナル |
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| Outline of Final Research Achievements |
We investigated roles of muscarinic acetylcholine (ACh) receptor (mChR) in T lymphocytes in the differentiation of naive T cells. It has been shown that the activation of naive T cells affects the intracellular signaling system mediated by mAChR. However, it was revealed that mAChR is not involved in regulation of the differentiation of naive helper T cells, while α7 type nicotinic ACh receptor regulates that.
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