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Molecular mechanisms of hair follicle formation by Runx family proteins

Research Project

Project/Area Number 15K07980
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pharmacology in pharmacy
Research InstitutionRitsumeikan University

Principal Investigator

Fujita Takashi  立命館大学, 薬学部, 准教授 (30319793)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords毛包 / Tnfrsf19 / Shh / ケラチノサイト / 毛乳頭細胞 / Runxファミリー / Runx2 / 上皮 / 間葉 / 毛包形成 / Runx / 発毛
Outline of Final Research Achievements

Shh is a morphogenetic factor that is extremely important for hair formation. The mechanism upstream of Shh signal in early anagen was not clear. Expression pattern analysis of Tnfrsf 19 and transplantation test by patch method of genetically modified cells showed that the Tnfrsf 19 signal functions upstream of the Shh signal and is expressed in epidermal keratinocytes. We also found conditions under which Tnfrsf 19 expression is enhanced in cultured keratinocytes. These results provide a novel mechanism of the Tnfrsf 19-Shh pathway in the early stage of hair follicle formation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (2 results) (of which Int'l Joint Research: 2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] The Role of Interleukin-19 in Contact Hypersensitivity2018

    • Author(s)
      Fujimoto Y, Fujita T, Kuramoto N, Kuwamura M, Izawa T, Nishiyama K, Yoshida N, Nakajima H, Takeuchi T, Azuma YT.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 41 Issue: 2 Pages: 182-189

    • DOI

      10.1248/bpb.b17-00594

    • NAID

      130006329250

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fatty acid transport protein 1 enhances the macrophage inflammatory response by coupling with ceramide and c-Jun N-terminal kinase signaling2018

    • Author(s)
      Nishiyama K, Fujita T, Fujimoto Y, Nakajima H., Takeuchi T, Azuma YT
    • Journal Title

      International Immunopharmacology

      Volume: 55 Pages: 205-215

    • DOI

      10.1016/j.intimp.2017.12.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of PGC-1α activating constituents in Zingiberaceous crude drugs.2017

    • Author(s)
      Nishidono Y, Fujita T, Kawanami A, Nishizawa M, Tanaka K
    • Journal Title

      Fitoterapia

      Volume: 122 Pages: 40-44

    • DOI

      10.1016/j.fitote.2017.08.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Runx3 inhibits melanoma cell migration through regulation of cell shape change.2017

    • Author(s)
      Zhang X, Wang L, Zeng X, Fujita T, Liu W
    • Journal Title

      Cell Biology International

      Volume: 41 Issue: 9 Pages: 1048-1055

    • DOI

      10.1002/cbin.10824

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective and therapeutic effects of fucoxanthin against sunburn caused by UV irradiation2016

    • Author(s)
      Matsui M, Tanaka K, Higashiguchi N, Okawa H, Yamada Y, Tanaka K, Taira S, Aoyama T, Takanishi M, Natsume C, Takakura Y, Fujita N, Hashimoto T, Fujita T
    • Journal Title

      Journal of Pharmacological Science

      Volume: 132 Issue: 1 Pages: 55-64

    • DOI

      10.1016/j.jphs.2016.08.004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Fucoxanthinol attenuates triacylglycerol content in mature adipocytes and oxidative stress-induced muscle atrophy in skeletal muscle cells.2016

    • Author(s)
      Maki YOSHIKAWA, Takashi FUJITA, Masashi HOSOKAWA, Kazuo MIYASHITA, Hoyoku NISHINO, Takeshi HASHIMOTO
    • Organizer
      Obesity week 2016
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2016-10-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of Fucoxanthinol on lipolytic activity in 3T3-L1 adipocytes.2016

    • Author(s)
      Maki YOSHIKAWA, Takashi FUJITA, Masashi HOSOKAWA, Kazuo MIYASHITA, Hoyoku NISHINO, Takeshi HASHIMOTO
    • Organizer
      Annual Congress of the European College of Sport Science
    • Place of Presentation
      Vienna, Austlia
    • Year and Date
      2016-07-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] ITCH SUPPRESSION BY FUCOXANTHIN2016

    • Inventor(s)
      Takashi Fujita
    • Industrial Property Rights Holder
      Ritsumeikan, Logic Co., Ltd
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-04-20
    • Acquisition Date
      2017-02-14
    • Related Report
      2016 Research-status Report
    • Overseas

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Published: 2015-04-16   Modified: 2019-03-29  

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