Molecular mechanisms of hair follicle formation by Runx family proteins

• Project/Area Number: 15K07980
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pharmacology in pharmacy
• Research Institution: Ritsumeikan University
• Principal Investigator: Fujita Takashi 立命館大学, 薬学部, 准教授 (30319793)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 毛包 / Tnfrsf19 / Shh / ケラチノサイト / 毛乳頭細胞 / Runxファミリー / Runx2 / 上皮 / 間葉 / 毛包形成 / Runx / 発毛

Outline of Final Research Achievements

Shh is a morphogenetic factor that is extremely important for hair formation. The mechanism upstream of Shh signal in early anagen was not clear. Expression pattern analysis of Tnfrsf 19 and transplantation test by patch method of genetically modified cells showed that the Tnfrsf 19 signal functions upstream of the Shh signal and is expressed in epidermal keratinocytes. We also found conditions under which Tnfrsf 19 expression is enhanced in cultured keratinocytes. These results provide a novel mechanism of the Tnfrsf 19-Shh pathway in the early stage of hair follicle formation.

Research Products

• [Journal Article] The Role of Interleukin-19 in Contact Hypersensitivity (2018)
  • Author(s): Fujimoto Y, Fujita T, Kuramoto N, Kuwamura M, Izawa T, Nishiyama K, Yoshida N, Nakajima H, Takeuchi T, Azuma YT.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 41 Issue: 2 Pages: 182-189
  • DOI: 10.1248/bpb.b17-00594
  • NAID: 130006329250
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fatty acid transport protein 1 enhances the macrophage inflammatory response by coupling with ceramide and c-Jun N-terminal kinase signaling (2018)
  • Author(s): Nishiyama K, Fujita T, Fujimoto Y, Nakajima H., Takeuchi T, Azuma YT
  • Journal Title: International Immunopharmacology Volume: 55 Pages: 205-215
  • DOI: 10.1016/j.intimp.2017.12.003
  • Peer Reviewed
• [Journal Article] Identification of PGC-1α activating constituents in Zingiberaceous crude drugs. (2017)
  • Author(s): Nishidono Y, Fujita T, Kawanami A, Nishizawa M, Tanaka K
  • Journal Title: Fitoterapia Volume: 122 Pages: 40-44
  • DOI: 10.1016/j.fitote.2017.08.007
  • Peer Reviewed
• [Journal Article] Runx3 inhibits melanoma cell migration through regulation of cell shape change. (2017)
  • Author(s): Zhang X, Wang L, Zeng X, Fujita T, Liu W
  • Journal Title: Cell Biology International Volume: 41 Issue: 9 Pages: 1048-1055
  • DOI: 10.1002/cbin.10824
  • Peer Reviewed
• [Journal Article] Protective and therapeutic effects of fucoxanthin against sunburn caused by UV irradiation (2016)
  • Author(s): Matsui M, Tanaka K, Higashiguchi N, Okawa H, Yamada Y, Tanaka K, Taira S, Aoyama T, Takanishi M, Natsume C, Takakura Y, Fujita N, Hashimoto T, Fujita T
  • Journal Title: Journal of Pharmacological Science Volume: 132 Issue: 1 Pages: 55-64
  • DOI: 10.1016/j.jphs.2016.08.004
  • Peer Reviewed / Open Access
• [Presentation] Fucoxanthinol attenuates triacylglycerol content in mature adipocytes and oxidative stress-induced muscle atrophy in skeletal muscle cells. (2016)
  • Author(s): Maki YOSHIKAWA, Takashi FUJITA, Masashi HOSOKAWA, Kazuo MIYASHITA, Hoyoku NISHINO, Takeshi HASHIMOTO
  • Organizer: Obesity week 2016
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-10-31
  • Int'l Joint Research
• [Presentation] The effect of Fucoxanthinol on lipolytic activity in 3T3-L1 adipocytes. (2016)
  • Author(s): Maki YOSHIKAWA, Takashi FUJITA, Masashi HOSOKAWA, Kazuo MIYASHITA, Hoyoku NISHINO, Takeshi HASHIMOTO
  • Organizer: Annual Congress of the European College of Sport Science
  • Place of Presentation: Vienna, Austlia
  • Year and Date: 2016-07-06
  • Int'l Joint Research
• [Patent(Industrial Property Rights)] ITCH SUPPRESSION BY FUCOXANTHIN (2016)
  • Inventor(s): Takashi Fujita
  • Industrial Property Rights Holder: Ritsumeikan, Logic Co., Ltd
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-04-20
  • Acquisition Date: 2017-02-14
  • Overseas