Angiotensin induces vasoconstriction and vasorelaxation via Rho-kinase.
| Project/Area Number |
15K07984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小野寺 章 神戸学院大学, 薬学部, 助教 (40598380)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | アンジオテンシン / ミオシン軽鎖ホスファターゼ / 血管収縮 / Rho-キナーゼ / MAPK / Rhoキナーゼ |
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| Outline of Final Research Achievements |
Angiotensin II (Ang II), the most active component of the renin-angiotensin system, is a multifunctional hormone that plays an important role in the cardiovascular physiology and pathology. The activation of the Ang II receptor mediates vasoconstriction and proliferation of vascular smooth muscle cell. The aim of this study was to determine the mechanism underlying Ang II-induced vasoconstriction of rat aorta. Ang II-induced constriction was significantly blocked by Rho kinase inhibitor, extracellular signal-regulated kinase 1 and 2 (Erk1/2) inhibitor, epidermal growth factor receptor (EGFR) inhibitor, and Src inhibitor. Phosphorylation of myosin phosphatase target subunit 1 (MYPT1, an index of Rho kinase activity) was abrogated by inhibitors of Src, EGFR, Erk1/2, and Rho kinase. These results suggest that Ang II induced vasoconstriction in rat aorta via Src, EGFR, MEK, and Erk1/2 activation, leading to the inactivation of myosin light chain phosphatase via phosphorylation of MYPT1.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Amorphous nanosilica particles evoke vascular relaxation through PI3K/Akt/ eNOS signaling2016
Author(s)
Akira Onoderaa, Katsutoshi Yayamaa, Atsushi Tanakaa, Hideto Morosawaa, Takuya Furutaa, Naoya Takedaa, Kisa Kakiguchib, Shigenobu Yonemurab, Itaru Yanagiharac, Yasuo Tsutsumid, Yuichi Kawaia
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Journal Title
Fundamental & Clinical Pharmacology
Volume: ３０
Pages: 419-428
Related Report
Peer Reviewed / Open Access
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