| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Ischemic tolerance is an endogenous process that provides robust neuroprotection. To clarify the roles of protein post-translational modification in tolerance to ischemia, protein SUMOylation in the hibernating hamster which is a natural model of tolerance to cerebral ischemia/reperfusion was investigated. Our results revealed that increased SUMO2/3 modification depended on the levels of hypothermia. In addition, we found that protein SUMO2/3 modification induced by hypothermia provided neuroprotection in cerebral ischemia/reperfusion injury. Furthermore, we showed that protein SUMO2/3 modification induced by hypothermia inhibited the decreases in core body temperature.
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