| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
Epidermal growth factor (EGF) is protein factors which enhance survival, maintenance and neurite outgrowth of midbrain dopaminergic neurons. To evaluate a potential neuroinflammatory role of the EGF, we examined the neurobehavioral consequences of EGF administration as well as its effects on inducible prostaglandin synthetase (cyclooxygenase 2; Cox-2) expression in mice. Neuroinflammation is also implicated in a number of developmental disorders. Inducing of EGF to mice showed social behavioral abnormalities which are related with enhances of the expression of Cox-2. However mice with social behavioral dysfunction exhibited normal locomotor and learning activities and normal expression levels of dopaminergic neuron related proteins and dopamine metabolism. We conclude this EGF-triggered neuroinflammatory process is mediated in part by Cox-2 activity in developmental stages of around postnatal day14 to generate neurobehavioral abnormalities.
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