| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this project, I have attempted comprehensive understanding and elucidation of the biosynthetic genes of daurichromenic acid, a meroterpenoid with a potent anti-HIV activity isolated from a medicinal plant Rhododendron dauricum. I have successfully cloned genes coding for polyketide synthase, prenyltransferase, and oxidocyclase (DCA synthase) that constitute the DCA pathway. This study comprehensively identified the biosynthetic genes and established the heterologous expression system of each biosynthetic enzyme to develop the biotechnological production of daurichromenic acid.
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