Saponin production based on chemical variation of Glycyrrhiza plants
| Project/Area Number |
15K07999
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 甘草 / サポニン / カンゾウ属植物 / 成分変異 / グリチルリチン酸 / Glycyrrhiza |
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| Outline of Final Research Achievements |
A glycyrrhizin(GL)-high-producing Glycyrrhiza uralensis strain (T628) was selected from various strains of Glycyrrhiza plants, and characterizations of the T628 strain and its offspring were performed to obtain better GL -high-producing strains. In addition, chemical characterization of Glycyrrhizin-Deficient-G. uralensis strains (83-555) were performed to isolate glucoglycyrrhizn (GGL), a unique analogue of GL. Offspring of 83-555 were characterized to obtain a vigorously-growing and GGL-producing strain (83-555-3-12) derived from a hybrid (83-555-3) of 83-555. Furthermore, Glycyrrhiza bucharica, an endemic Glycyrrhiza plant in Tajikistan, was shown to be closely related to GL -producing Glycyrrhiza species, G. uralensis, G. glabra and G. inflata, based on their chloroplast rbcL sequences, whereas G. bucharica do not produce GL. Four new triterpene glycosides, bucharosides A, B, C, D, were isolated and characterized from the underground parts of G. bucharica.
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Report
(4 results)
Research Products
(10 results)
