| Project/Area Number |
15K08002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
福村 基徳 昭和大学, 薬学部, 講師 (00407529)
小池 佑果 昭和大学, 薬学部, 助教 (10644479)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 老化 / 活性酸素 / 漢方 / 生薬 / 線虫 / 生薬・漢方 / SIRT1 / 抗酸化 |
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| Outline of Final Research Achievements |
Oxidative stress is closely related to aging and lifespan. We developed the screening method for antioxidant with combination of extracellular, intracellular, and an individual level using aging animal C. elegans. In the course of search for antioxidant, we found that the root extract of Angelica pubescens MAXIM (Umbeliferae) showed antioxidant effect on extracellular and intracellular level. But it did not show a life-extending effect on C. elegans. Interestingly, the extract led to activation of human longevity genes SIRT1. As results of active guided fractionation, seven coumarins were isolated as activaters of SIRT1.
In the course of exhaustive research for Kampo medicines as anti-aging, we found that several formulations for ki (energy) and formulations for oketu (stagnation of blood circulation) extended longevity of C. elegans. Among them, Hochuekkito led to 20% longer lifespan of C. elegans.
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