| Project/Area Number |
15K08003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Toho University |
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Principal Investigator |
KOIKE Kazuo 東邦大学, 薬学部, 教授 (30130363)
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| Co-Investigator(Kenkyū-buntansha) |
李 巍 東邦大学, 薬学部, 准教授 (90328633)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 医療用漢方製剤 / 糖代謝異常疾患 / 麻子仁丸 / 漢方薬 / 抗酸化作用 / 大柴胡湯 / 治打撲一方 / 通導散 / 糖尿病 / 抗酸化活性 / プロティンチロシンホスファターゼ1B / AGEs / aldose reductase |
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| Outline of Final Research Achievements |
The study comprehensively evaluated the effects of all oral Kampo preparations on the molecular targets in glucose metabolism disorders. As a result,Daiokanzoto, Masiningan, Tokakujokito, Keimakakuhanto and Choijokito exhibited the highest inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a molecular target for insulin-resistant type 2 diabetes mellitus. On the other hand, Shin'iseihaito and Jidabokuippo showed inhibitory activity against advanced glycation end products (AGEs) and aldose reductase (AR) for diabetic complications, respectively. Furthermore,Tsudosan,Daisaiko and Masiningan showed the strongest antioxidant activity.
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